耳穴贴压配合柴胡解郁汤治疗卒中后抑郁临床研究  

Clinical Observation on Auricular Points Plaster Therapy Combined with Chaihu Jieyu Decoction Treatment of Post Stroke Depression

作　　者：毛光兰[1] 贾奎[2] 

机构地区：[1]新乡医学院第三附属医院,河南新乡453000 [2]新乡医学院第一附属医院,河南卫辉453003

出　　处：《中医学报》2015年第4期606-608,共3页Acta Chinese Medicine

基　　金：河南省中医药科研专项课题(2014ZY02089)

摘　　要：目的:观察耳穴贴压配合柴胡解郁汤治疗卒中后抑郁(post-stroke depression,PSD)的临床疗效,并对5-羟色胺(5-hydroxytryptamine,5-HT)递质水平进行监测和评价。方法:将120例PSD患者随机分为治疗组60例,对照组60例,对照组口服舍曲林片治疗。治疗组给予耳穴贴压配合柴胡解郁汤治疗,治疗8周后评价疗效,分别在治疗第2周、第4周、第8周给予记录汉密尔顿抑郁量表(hamilton depression scale,HAMD)评分、测定血清5-HT递质水平。结果:两组临床疗效比较,差异有统计学意义(P<0.05);两组HAMD评分,5-HT递质水平较治疗前明显下降,差异有统计学意义(P<0.01),两组治疗后比较,治疗组优于对照组,差异有统计学意义(P<0.05)。结论:耳穴贴压配合柴胡解郁汤治疗中风后抑郁疗效明显,其作用机制可能与其升高PSD患者血清5-HT递质水平密切相关。Objective： To observe the clinical curative effect of auricular points plaster therapy combined with Chaihu Jieyu Decoction in the treatment of post stroke depression （PSD） and to monitor and evaluate the level of 5-HT transmitter. Methods ： 120 cases of PSD were randomly divided into treatment group （60 cases） and control group （60 cases）. The treatment group was given auricular points plaster therapy combined with Chaihu Jieyu Decoction while the control group was given oral sertraline treatment. The curative effect was evaluated after 8 weeks＇ treatment. The score of HAMD was recorded and the level of 5-HT transmitters in serum was measured after 2, 4, 8 weeks＇ treatments, respectively. Results： After treatment, the clinical effect of treatment group was better than that of the control group （ P 〈 0.05 ）, the difference was statistically significant ; the HAMD score was significantly improved than pretherapy （ P 〈 0. 01 ） , and the difference between groups （ P 〈 0.05 ） was statistically significant. Compared to the control group, the score of HAMD （ P 〉 0.05 ） after 2 weeks showed no significant difference while showed significant difference after 4 weeks （ P 〈 0.05 ）. The comparison of the two groups at the same time nodes ： the HAMD score of the treatment group had significant difference compared to that of the con- trol group （P 〈 0.05 ） after 2 weeks＇ treatment. Conclusion： The therapeutic effect of auricular points plaster therapy combined with Chaihu Jieyu Decoction in the treatment of post stroke depression is significant, and its mechanism may be related to the increase of the level of 5-HT in the PSD patients＇ serum.

关 键 词：卒中后抑郁 柴胡解郁汤 耳穴贴压 舍曲林片 汉密尔顿抑郁量表 5-羟色胺 

分 类 号：R245.749[医药卫生—针灸推拿学]