松龄血脉康胶囊联合小剂量辛伐他汀治疗高脂血症临床疗效及对血清同型半胱氨酸影响  

Effect and Influenc on Serum Homocysteine of Songling Xuemaikang Capsule in the Treatment of Patients with Hyperlipidemia

作　　者：刘淑琴 李步满[2] 

机构地区：[1]北京市石景山区老山社区卫生服务中心全科,北京100049 [2]北京大学首钢医院,北京100144

出　　处：《辽宁中医药大学学报》2015年第5期208-210,共3页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:观察松龄血脉康胶囊联合辛伐他汀治疗高脂血症的临床疗效及对血清同型半胱氨酸的影响,为临床治疗提供借鉴。方法:选择80例符合入组标准的高脂血症作为研究对象,按随机数字表分为观察组40例和对照组40例,对照组单纯给予常规剂量的辛伐他汀治疗,20 mg/次,日1次,观察组给予松龄血脉康胶囊联合小剂量辛伐他汀治疗,辛伐他汀10 mg/次,日1次,松龄血脉康胶囊3粒/次,日3次,30 d为1个疗程,观察患者症状、体征改善情况,进行血浆同型半肌氨酸及血脂指标(总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白)检测,评价血脂疗效、中医证候疗效,观察不良反应发生情况。结果:(1)观察组和对照组治疗后血浆同型半胱氨酸、总胆固醇、甘油三酯、低密度脂蛋白较治疗前明显下降,高密度脂蛋白较治疗前明显升高,观察组治疗后血浆同型半胱氨酸、总胆固醇、甘油三酯、低密度脂蛋白明显低于对照组,高密度脂蛋白明显高于对照组。(2)观察组的中医症候疗效为85%,对照组为72.5%,差异具有统计学意义,χ2=8.023,P<0.05,观察组的血脂总疗效为85%,对照组为70%,差异具有统计学意义,χ2=8.520,P<0.05。(3)观察组出现1例胃肠道反应(恶心、腹胀),对照组出现5例胃肠道反应,1例氨基转移酶升高,肌酸激酶轻度升高2例,观察组的不良反应明显低于对照组,χ2=6.135,P<0.05。结论:松龄血脉康胶囊联合小剂量辛伐他汀治疗高脂血症能安全、有效控制血脂异常,可降低大剂量辛伐他汀引起的不良反应,起到增效减副作用,提高患者耐受性及依从性,适合长期服用,值得临床推广使用。Objective： To observe the effect and influenc on serum homocysteine ofSongling Xuemaikang Capsule in the treatment of hyperlipidemia, and provide reference for clinical treatment.Methods ： 80 patients with hyperlipidemia met the inclusion criteria were included as research object, all the patients were randomly divided into observation group （ 40 cases ） and the control group （ 40 cases ）, the control group were given regular doses of simvastatin, 20 mg/times, qd, the observation group were received Songling Xuemaikang Capsule and low-dose simvastatin, simvastatin 10 rag/times, qd, Songling Xuemaikang Capsule 3 granule one time, tid, 30d for a course, symptoms and signs were observed, semi plasma creatine and serum lipids （ total cholesterol, triglyeerides, high density lipoprotein, low-density lipoprotein ） were detected, the lipid efficacy and traditional Chinese medicine symptoms efficacy..were evaluated, adverse reactions were observed. Results ： （ 1 ） The serum homocysteine, TC, TG, LDL-C of observation group and control group after treatment were lower than before treatment, HDL-C were higher than before treatment, the serum homocysteine, TC, TG, LDL-C of observation group after treatment were lower than control group, HDL-C were higher than control group. （ 2 ） The traditional Chinese medicine efficacy of observation group was 85%, the control group was 72.5%, the difference was statistically significant, χ^2=8-023, P〈0.05, the total lipid efficacy of observation group was 85%, the control group was 70%, the difference statistically significant, χ^2=8-520, P〈0.05. （ 3 ） There was 1 patient with gastrointestinal side effects （ nausea, bloating ） in the observation group, and there were 5 patients with gastrointestinal side effects, 1 patient with aminotransferase and 2 patients with creatine kinase elevated, the rate of adverse reactions in the observation group were significantly lower than the control group, χ^2=6-135, P〈0.05.Conclusion： The method containing S

关 键 词：高脂血症 松龄血脉康胶囊 小剂量辛伐他汀 血清同型半胱氨酸 疗效 

分 类 号：R589.2[医药卫生—内分泌]