中国楤木总皂苷对糖尿病大鼠血糖、血脂的影响  

Effects of Total Saponin from Aralia chinensis on Blood Glucose and Lipid in Diabetic Rat

作　　者：赵博[1] 王一峰[1] 侯宏红 靳洁[1] 曹家豪 殷虎虎 

机构地区：[1]西北师范大学生命科学学院,中国甘肃兰州730070

出　　处：《生命科学研究》2015年第2期137-140,144,共5页Life Science Research

基　　金：国家自然科学基金面上项目(C030401);甘肃省自然科学基金项目(1208RJZA-126);兰州市科技局技术支撑项目(2013-4-28);甘肃省生态生物学重点学科项目

摘　　要：通过四氧嘧啶(alloxan,ALX)诱导建立糖尿病大鼠模型,用中国楤木总皂苷(total saponins of Aralia chinensis,SAC)高、中、低剂量和二甲双胍分别对糖尿病大鼠每天进行灌胃给药,并同时设有正常组、糖尿病模型组,每天灌胃等体积生理盐水,连续4周,观察大鼠空腹血糖(FBG)、糖化血红蛋白(Hb Alc)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)的变化。发现SAC对糖尿病大鼠FBG、Hb Alc有明显降低作用,同时降低TC、TG,升高HDL含量。结果表明SAC能够降低糖尿病大鼠血糖,调节糖尿病大鼠血脂代谢紊乱。Effects of total saponin from A ralia chinensis on blood glucose and lipid was evaluated in diabetic model rat by administration of high-dosage, medium-dosage, low-dosage of total saponin for four weeks, and mefformin hydrochloride and normal saline for stomach perfusion were used a positive and negative control, respectively. Fasting blood glucose （FBG）, glycosylated hemoglobin （HbAlc）, total cholesterol （TC）, triglyc- eride 1 （TG）, high density lipoprotein （HDL） and low density liporotein （LDL）were monitored. Results showed that SAC can significantly reduce the level of FBG and HbAlc in diabetic rat and TC and TG in serum, meantime the HDL level were elevated. SAC may be a potential therapeutic agent for diabetes.

关 键 词：中国楤木 总皂苷 糖尿病大鼠 血糖 血脂 

分 类 号：Q946.3[生物学—植物学]