加味八珍汤联合催产素对足月妊娠孕妇宫颈成熟影响的临床研究  

Clinical study of Jiawei Bazhen decoction combined with oxytocin for cervical ripening of qi and blood deficiency type of pregnant women

作　　者：柯晓燕[1] 陈宝艳[1] 徐慧芳[1] 李道成[1] 李艳芳[1] 孙雪[1] 

机构地区：[1]广州中医药大学第一附属医院,广东广州510405

出　　处：《中国中药杂志》2015年第9期1821-1824,共4页China Journal of Chinese Materia Medica

基　　金：广东省中医药局基金项目(20131175)

摘　　要：通过对辨证为气血虚弱型的足月妊娠孕妇选用加味八珍汤口服,联合应用催产素的观察,初步探讨加味八珍汤联合催产素对于促进妊娠足月孕妇宫颈成熟的作用。本研究采用随机对照的试验方法,将符合纳入标准的研究对象180例,随机分为治疗组即加味八珍汤联合催产素组60例,对照组即催产素组60例,空白组即期待观察组60例。观察用药前后各组宫颈成熟度评分(Bishop评分)、阴道和宫颈分泌物胎儿纤连蛋白(FFN)定性检测结果、分娩结局及对母胎的影响。结果表明,治疗组孕妇宫颈评分在用药后明显优于对照组、空白组(P<0.05)。FFN测定在治疗组用药后与对照组、空白组间差异有统计学意义(P<0.05)。3组孕妇用药后治疗组临产率、阴道分娩率均高于其他2组,差异有统计学意义(P<0.05)。治疗组剖宫产率明显低于其他2组,差异有统计学意义(P<0.05)。3组均未出现新生儿窒息的现象。加味八珍汤联合催产素能有效地促宫颈成熟和引产,使用方便、安全可靠,对母儿无明显不良影响,在降低剖宫产率,促进自然分娩上起到积极作用。To study preliminarily the effect of Jiawei Bazhen decoction combined with oxytocin in promoting cervical ripening of full- term pregnancy women who were in the deficiency of qi and blood type through the syndrome differentiation of traditional Chinese medi- cine （TCM）. 180 patients that met the inclusion criteria of the study were randomly divided into three groups： the control group （oxyto- cin group）, the treatment group （Jiawei Bazhen decoction combined with oxytocin group）, the blank control group （expected and ob- servation group）. Cervical maturity score（ Bishop score）, vaginal and cervical secretions fetal fibronectin （FFN）, the result of induced labor, the result of mother and baby were observed in each group before and after treatment. The result comes out that the cervical Bishop score of pregnant women for treatment group were significantly higher than the control group and blank control group after treat- ment （ P 〈 O. 05 ）. The FFN of pregnant women for the treatment group were significantly different from the control group and blank control group after treatment （ P 〈 O. 05 ）. The pregnancy outcome of the three groups ： the labor rate and rate of vaginal delivery of the treatment group were higher than the other two groups , and the difference was statistically significant （ P 〈 O. 05 ）. The cesarean sec- tion rate of the treatment group was significantly lower than the other two groups, the difference was also statistically significant （ P 〈 0.05）. The three groups did not appear the phenomenon of neonatal asphyxia. Jiawei Bazhen decoction combined with oxytocin is ef- fective in producing cervical ripening and induce labor. It is convenient, safe and reliable, for it is no obvious adverse effects on moth- er and fetus , but effective in reducing the rate of cesarean section, and playing a positive role in promoting natural delivery.

关 键 词：加味八珍汤 催产素 宫颈成熟 

分 类 号：R719.31[医药卫生—妇产科学]