加味黄芪赤风汤治疗IgA肾病蛋白尿临床研究  

Clinical Study on the Supplemented Huangqi Chifeng Decoction for Treating IgA Nephrotic Proteinuria

作　　者：王华 

机构地区：[1]辽阳市第四人民医院,辽宁辽阳111000

出　　处：《河南中医》2015年第4期785-787,共3页Henan Traditional Chinese Medicine

基　　金：辽宁省自然科学基金项目(编号:20102149)

摘　　要：目的:探讨加味黄芪赤风汤治疗IgA肾病蛋白尿的临床疗效及药理机制。方法:选取IgA肾病蛋白尿患者32例,采用随机数字表法分为对照组和观察组各16例。对照组给予替米沙坦治疗,观察组给予加味黄芪赤风汤治疗。结果:治疗3个月后,两组血肌酐水平比较无统计学意义(P>0.05);观察组24 h尿蛋白水平、中医证候积分均优于对照组(P均<0.05)。结论:加味黄芪赤风汤可有效降低IgA肾病尿蛋白水平和中医证候积分,对血肌酐水平无明显影响。Objective：To discuss the clinical effect and pharmacological mechanism of Supplemented Huangqi Chifeng Decoction. Methods：32 cases with IgA Nephrotic Proteinuria were randomized into control group （16 cases） given Telmisartan and observa- tion group （ 16 cases） given Supplemented Huangqi Chifeng Decoction. Results：After 3 months of treatment,the difference of ser- um creatinine levels in two groups had no statistical significance （P 〉 0.05 ）. At the 24h of the treatment, the level of proteinuria and score of TCM symptoms were both better than these in control grnup （ P 〈 0.05 ）. Conclusion ： Supplemented Huangqi Chifeng Decoction can effectively lower the level of IgA nephrotic proteinuria and score of TCM symptoms, but there is significant influence on the level of serum creatinine.

关 键 词：IgA肾病蛋白尿 加味黄芪赤风汤 血肌酐 24 h尿蛋白 

分 类 号：R259.962[医药卫生—中西医结合]