香莲栓联合咪康唑栓对单纯性外阴阴道念珠菌病增效作用研究  

Clinical Study of Synergistic Effect of Xianglian Suppository Combined with Miconazole Suppository in Treating Simple Vulvovaginal Candidiasis

作　　者：吴盘红[1] 范瑞强[2] 陈信生[2] 谢婷[2] 

机构地区：[1]河南省中医院皮肤科,河南郑州450002 [2]广东省中医院皮肤科,广东广州510120

出　　处：《广州中医药大学学报》2015年第3期415-417,422,共4页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金："十一.五"国家科技支撑计划项目(编号:2008BAI53B041);广东省自然科学基金项目(编号:S2011040003509)

摘　　要：【目的】观察香莲栓和咪康唑栓联合治疗单纯性外阴阴道念珠菌病(VVC)的抗菌增效作用,探讨中西医结合治疗外阴阴道念珠菌病的优势。【方法】将65例患者随机分为试验组35例和对照组30例。试验组给予香莲栓和咪康唑栓治疗,对照组给予咪康唑栓治疗,共用药7 d。观察2组治疗前后证候积分的变化情况,评价2组的临床疗效及安全性。【结果】(1)经1个疗程治疗后,试验组的愈显率和总有效率分别为60.00%、88.57%,优于对照组的23.33%、60.00%(均P<0.01)。(2)治疗后,2组的证候积分均较治疗前显著降低(P<0.01),且试验组在改善证候积分方面作用优于对照组(P<0.01)。(3)安全性方面:试验组中有1例诉使用后自觉外阴瘙痒加重,检查发现外阴阴道潮红,无肿,无水疱,无其他不适,嘱继续用药后患者症状消失,不考虑为过敏反应;对照组无1例出现过敏等不适表现。【结论】香莲栓和咪康唑栓联合治疗单纯性外阴阴道念珠菌病,可明显改善临床症状,且安全性好,值得在临床推广应用。Objective To observe the antibacterial and synergistic effect of Xianglian Suppository with miconazole suppository for the treatment of simple vulvovaginal candidiasis （ VVC） , and to explore the advantages of integrative Chinese and western medicine for the treatment of simple VVC. Methods According to the principle of randomized trial, 65 simple VVC patients were divided into two groups, 35 cases in test group and 30 in＆nbsp;control group. The test group was given Xianglian suppository and miconazole suppository, and the control group was treated with miconazole suppository, the medication lasting for 7 days. The changes of symptom scores before and after treatment were observed, and the therapeutic effect and safety were also evaluated in both groups. Results （ 1） After treatment for one course, the markedly effective rate and total effective rate were 60.00%, 88.57% in the test group, and were 23.33%, 60.00% in the control group, respectively, the differences being significant between the two groups （ P〈0.01）. （ 2） After treatment, symptom scores were decreased in both groups （ P〈0.01 compared with those before treatment） , and the decrease in the test group was superior to that in the control group （P〈0.01）. （3） One case of the test group had the complaint of severer pruritus vulvae after medication, and the results of physical examination showed the case had vulvovaginal flush but had no edema, blister or other discomfort. The manifestations disappeared when the medication continued, indicating that the case had no allergic reaction. No case had allergic reaction in the control group. Conclusion For the treatment of simple VVC, Xianglian suppository combined with miconazole suppository can obviously relieve the clinical symptoms, and is effective and safe.

关 键 词：单纯性外阴阴道念珠菌病/中西医结合疗法 香莲栓/治疗应用 咪康唑栓/治疗应用 

分 类 号：R711.31[医药卫生—妇产科学]