剂量密集方案在乳腺癌新辅助化疗中的应用  

Dose-Dense Neoadjuvant Chemotherapy for Breast Cancer

作　　者：朱腾[1,2] 张一方[2] 李玲娟[2] 王坤[2] 

机构地区：[1]汕头大学医学院,广东汕头515041 [2]广东省人民医院肿瘤中心乳腺科,广东省医学科学院,广州510080

出　　处：《循证医学》2015年第2期126-128,共3页The Journal of Evidence-Based Medicine

基　　金：广东省科技厅计划项目(2012B031800405)

摘　　要：剂量密集化疗是指在单次化疗剂量不变的前提下,缩短每次化疗之间的时间间隔,以达到更好的疗效。以往的研究表明相对于传统的化疗方案,剂量密集方案在乳腺癌辅助化疗中的疗效是值得肯定的,这一点尤其体现在无疾病生存期和总生存期方面。但目前关于其在乳腺癌新辅助化疗中的应用存在争议。本文旨在阐述剂量密集方案理论基础的同时,总结近年关于剂量密集方案在乳腺癌新辅助化疗上的进展。Dose-dense chemotherapy is a strategy to reduce the interval between each dose of chemotherapy with the same amount of drug and to achieve the maximal effectiveness of chemotherapy. Several trials have demonstrated that dose-dense adjuvant chemotherapy could achieve longer disease-free survival and overall survival comparing with conventionally-dosed chemotherapy. However, the value of dose-dense neoadjuvant chemotherapy is currently not clear. This review aims to outline the theoretical base of dose-dense chemotherapy and to summarize the progress of dose- dense neoadjuvant chemotherapy for breast cancer.

关 键 词：乳腺癌 剂量密集 新辅助化疗 

分 类 号：R737.9[医药卫生—肿瘤]