白细胞介素-17A在AR患者鼻粘膜中的表达及意义  

Expression and significance of interleukin-17A in the nasal mucosa of patients with allergic rhinitis

作　　者：刘卫卫[1] 王洪琴[1] 李健[1] 代保强[1] 江雪[1] 苏小明[1] 许鹏[1] 金爱燕 左文娜[1] 

机构地区：[1]沧州市中心医院,河北沧州061000

出　　处：《中国热带医学》2015年第2期141-144,共4页China Tropical Medicine

摘　　要：目的观察白细胞介素-17A（IL-17A）在变应性鼻炎（AR）患者鼻粘膜中的表达,探讨其意义。方法 2013年6月~2014年6月,收集AR患者40例（AR组）和非AR患者25例（对照组）,对其临床症状进行评分,测定每个受试者的血清免疫球蛋白E（Ig E）和嗜酸性6粒细胞含量;取鼻粘膜组织,用免疫组织化学技术（IHC）检测IL-17A的表达,ELI-SA检测IL-17A的含量,分析鼻粘膜组织IL-17A的表达量与患者临床症状评分、血清中Ig E含量及血液中酸性粒细胞含量的相关性。结果 IL-17A主要在浸润的炎性细胞中表达,组织中IL-17A的表达量与AR的症状评分呈正相关（R^2=0.815,P=0.001）,与血清中Ig E含量不相关（R^2=0.06,P=0.11）,与血液中嗜酸性粒细胞含量不相关（R^2=0.11,P=0.06）。结论在鼻腔黏膜上IL-17A的表达与变应性鼻炎的严重程度相关。Objective To investigate the expression of interleukin- 17A（IL- 17A） in nasal mucosa of patients withallergic rhinitis（AR）. Methods Forty patients with AR from March 2013 to March 2014 were selected as AR group andtwenty-five patients with non-AR（control group）. The score of clinical symptoms were evaluated. And IL- 17 A expressionbetween two groups was detected by immunohistochemistry（IHC）. The serum immunoglobulin E（Ig E） and IL- 17 A weredetected by ELISA to analyze the correlation between clinical symptoms score and IL-17 A expression.Results IL-17 A wasexpressed in inflammatory cells. The IL-17 A expression level were positively correlated with AR symptom scores（χ^2= 0.815,P = 0.001）, and was not related with serum Ig E levels（χ^2= 0.06, P = 0.11） and was not related with serum eosinophil cellcontent（χ^2= 0.11, P = 0.06）. Conclusion IL-17 A expression in the nasal mucosa was associated with nasal severity ofallergic rhinitis.

关 键 词：变应性鼻炎 白细胞介素-17A 炎症 嗜酸性粒细胞 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]