血清降钙素原与血浆脂多糖联合检测在发热患者中的价值  

Value of combined detection of PCT and LPS in diagnosis of feverish patients

作　　者：陈少文[1] 林翀[1] 吴智明[1] 李婵[2] 廉芳[1] 苏应仙 林明冠 

机构地区：[1]海南省农垦总医院检验科,海南海口570311 [2]海南医学院检验医学系,海南海口570311

出　　处：《中国热带医学》2015年第3期374-376,共3页China Tropical Medicine

摘　　要：目的血清降钙素原(Procalcitonin,PCT)与血浆脂多糖(Lipopolysaccharide,LPS)联合检测在发热患者的价值讨探。方法血清PCT采用半定量免疫色谱法检测,血浆LPS采用光度法定量检测,同时对患者进行血液培养。结果 940例发热患者中血培养细菌、PCT、LPS阳性率分别为30.5%、38.6%和41.3%。LPS和PCT两者同时阳性190例,占20.2%。血培养阳性287例患者中,G-菌阳性率为60.6%明显高于G+菌的33.4%及真菌的5.9%。PCT、LPS诊断细菌感染的敏感性分别为62.0%和74.2%,特异性分别为71.7%和73.2%。结论发热患者PCT或LPS阳性均与细菌感染密切相关,PCT与LPS之间有良好的正相关性,即PCT和LPS对发热待查患者病因诊断有较大意义。Objective To explore the value of the combined detection of serum procalcitonin（PCT） andlipopolysaccharide（LPS） in diagnosis of patients with fever. Methods Semi-quantitative immune chromatography（PCT-Q）and photometric quantitative methods were used to test the serum PCT and LPS in patients with fever. Blood cultures were alsoperformed. Results The positive rate of blood cultures, PCT and LPS in the 940 fever patients were 30.5%,38.6% and41.3%,, respectively. One hundred and ninety patients were both positive for LPS and PCT, accounting for 20.2%. Among the287 cases positive for blood cultures,, the detection rate of G-bacteria（60.6%） was significantly higher than that of G＋bacteria（33.4%） and fungi（5.9%）. The sensitivity of PCT and LPS for bacterial infection were 62.0% and 74.2%, and the specificitywere 71.7%,73.2%. Conclusion Serum PCT or（and） LPS positive value were closely related with bacterial infection,andPCT was positively correlated with LPS.PCT and LPS were valuable in diagnosis of feverish patients.

关 键 词：降钙素原 脂多糖 发热 实验诊断 

分 类 号：R441.3[医药卫生—诊断学]