HLA-B＊1502基因多态性与肾移植受者环孢素所致肝功能异常的相关性研究  

Association of HLA-B ＊ 1502 Genetic Polymorphism with Cyclosporine-induced Liver Injury in Chinese Re- nal Transplant Recipients

作　　者：辛华雯[1] 刘慧明[1] 李元启 黄晖 赵丽 余爱荣[1] 李罄[1] 吴笑春[1] 李维亮[1] 熊磊[1] 

机构地区：[1]广州军区武汉总医院临床药理科,武汉430070 [2]湖北省药品(医疗器械)不良反应监测中心

出　　处：《中国药师》2015年第5期704-707,共4页China Pharmacist

基　　金：湖北省自然科学基金计划资助项目(2009CDB010;2011CDC074)

摘　　要：目的:研究肾移植术后患者HLA-B*1502基因多态性对环孢素(Cs A)所致肝功能异常的影响。方法:采用PCR-SSP(顺序特异引物聚合酶链反应)方法对339名服用Cs A的肾移植患者进行HLA-B*1502基因多态性检测,根据肾移植患者发生肝脏损伤的情况分为Cs A致肝功异常组、其他原因肝损伤组和对照组。结果:在339名肾移植患者中HLA-B*1502等位基因频率为22.64%。HLA-B*1502多态性在Cs A致肝功异常组、其他原因肝损伤组和对照组三组之间的分布频率差异无统计学意义(P>0.05)。HLA-B*1502基因型组间各临床资料差异均无统计学意义(P>0.05)。结论:HLA-B*1502基因多态性与Cs A所致的肝功异常无明显相关性。Objective： To investigate the effects of HLA-B ＊ 1502 genetic polymorphism on cyclosporine（ CsA）-induced liver injury in Chinese renal transplant recipients. Methods： HLA-B ＊ 1502 genotypes were determined ,by polymerase amplification chain reaction of sequence-specific primers（PCR-SSP） in a total of 339 renal transplant recipients receiving CsA. All the subjects were divided into the CsA-induced liver injury group, non-CsA-induced liver injury group and the control group according to the liver injury occurrence. Results： In the 339 renal transplant recipients, the frequency of HLA-B ＊ 1502 mutation allele was 22.64%. The distribution frequen- cy of HLA-B ＊ 1502 mutation allele had no significant difference among the three groups. There were no significant differences in the clinical characteristics of HLA-B ＊ 1502 genotypes among three groups （P 〉 0.05 ）. Conclusion： No association is observed between HLA-B ＊ 1502 genetic polymorphism and cyclosporine-induced liver injury in Chinese renal transplant recipients.

关 键 词：肾移植 环孢素 肝损伤 HLA—B＊1502基因 多态性 

分 类 号：R968[医药卫生—药理学]