Simulink药动学房室模型仿真应用的研究  

Study of Simulation Application of Simulink Pharmacokinetic Compartment Model

作　　者：陈伟[1] 王宇[1] 费小非[1] 谢兰桂[2] 李国辉[1] 

机构地区：[1]中国医学科学院肿瘤医院,北京100021 [2]中国食品药品检定研究院

出　　处：《中国药师》2015年第5期736-740,共5页China Pharmacist

摘　　要：目的:动态描述药物浓度在体内的不同时间的变化,了解体内药物的行为模式和规律,为个体化治疗和避免药物不良反应提供参考,为开展生理药物动力学模型动态描述奠定基础。方法:使用Simulink动态仿真处理二室模型,建立二室动态模型进行曲线拟合和参数估计,将结果与3P97软件拟合结果进行比较。结果:比较仿真结果与3P97软件拟合结果,两者无显著差异。结论:动态模型可以用于口服给药的二室模型的动态仿真。动态仿真结果更加直观,并纠正了3P97软件的拟合偏差。Objective：To dynamically describe the drug concentration change in different time in vivo to understand the in vivo be-havior patterns and rules of drugs, provide reference for performing individual treatment and avoiding adverse drug reactions and lay foundation for dynamic description of physiological pharmacokinetic model. Methods：A two-compartment model was established using Simulink dynamic simulation and used in curve fitting and parameter estimation. The results from the model were compared with those from 3P97 software. Results：There was no significant difference between the results from the dynamic model and those from 3P97 soft-ware. Conclusion：The dynamic model can be used to dynamically simulate two-compartment model for oral administration. The re-sults from the dynamic simulation are more direct, and can correct the fitting error in 3P97 software.

关 键 词：药物动力学 二室模型 动态仿真 

分 类 号：R969.1[医药卫生—药理学]