金茵清热口服液半仿生提取醇沉浓度优选  

Alcohol Concentration Optimization for Jinyin Qingre Oral Liquids Extracted by Semi-bionic Extraction(SBE)

作　　者：叶方[1] 李丽[2] 杨光义[1] 黄良永[1] 张晨宁[1] 魏晋宝 

机构地区：[1]湖北医药学院附属十堰市太和医院,湖北十堰442000 [2]湖北医药学院

出　　处：《中国药师》2015年第5期766-769,共4页China Pharmacist

基　　金：湖北医药学院科技创新团队项目(编号:2011CXG05)

摘　　要：目的:优选金茵清热口服液半仿生提取(SBE)液的醇沉浓度。方法:按比例分割法设立5个醇沉浓度30%、55%、61.25%、67.5%、80%进行平行试验。以绿原酸、栀子苷、丹酚酸B、总酚酸得率和干浸膏收率为指标进行考察,将各指标数据标准化处理,采用设定的加权系数进行综合评价得出综合评价值Y,根据Y值大小优选金茵清热口服液的SBE液醇沉浓度。结果:5个指标综合评价Y值由大到小的顺序为:30%>61.25%>55%>80%>67.5%。结论:结合口服液的澄明度问题与生产实际,以含醇量61.25%为最佳醇沉浓度。Objective： To optimize the alcohol concentration for Jinyin Qingre oral liquids extracted by semi-bionic extraction （SBE）. Methods：Using proportional division method to set up 5 alcohol concentration 30%,55%,61. 25%,67. 5%,80% for the ex-periment . The dried extract yield and the contents of chlorogenic acid ,geniposide,salviandic acid B and total phenolic acid were set up as indexes which were standardized as the comprehensive evaluation value （ Y） ,using the weighting coefficient had been set. Choosing the appropriate concentration by comparing the value of Y. Results：The order of comprehensive evaluation value was as follows：30%〉61. 25% 〉55% 〉80% 〉67. 5%. Conclusion：Combining the clarity of the oral liquids, the best alcohol concentration in SBE for Jinyin Qingre oral liquids is 61. 25%.

关 键 词：金茵清热口服液 半仿生提取 醇沉浓度 综合评价 

分 类 号：R284.2[医药卫生—中药学]