洛伐他汀保护同型半胱氨酸硫内酯对大鼠离体胸主动脉内皮损伤的机制研究  

A research of Lovastatin protection homocysteine sulfur lactones of rats in vitro thoracic aortic endothelial damage

作　　者：黄宁江[1] 阳晓[1] 黄海[1] 

机构地区：[1]永州职业技术学院,湖南永州425100

出　　处：《医药前沿》2015年第10期31-32,共2页Journal of Frontiers of Medicine

基　　金：湖南省教育厅高校科学研究项目（项目编号：10C0325）

摘　　要：目的：观察洛伐他汀保护同型半胱氨酸硫内酯（Homocyteine Thiolactone, HTL）对大鼠离体胸主动脉内皮损伤的作用，并探讨其机制。方法：大鼠离体胸主动脉血管环与HTL共孵育，诱导血管内皮损伤，检测血管内皮依赖性舒张反应，观察洛伐他汀保护HTL诱导血管内皮功能损伤的作用。结果：给予不同浓度洛伐他汀（10,20,40μmol/L）可明显改善HTL对血管环EDR的损伤，与HTL损伤组相比均有显著性差异（P＜0.05或P＜0.01）。结论：洛伐他汀呈浓度依赖性地拮抗HTL对血管内皮功能的损伤作用，其机制可能与抑制氧化应激，保护血管内皮的NO合成与释放有关。ObjectiveObservation of lovastatin protection homocysteine sulfur lactone （HTL） on in vitro thoracic aortic endothelial damage in rats, and to explore its mechanism. Methods Rats in vitro thoracic aorta vascular ring with HTL incubation, induce endothelial injury, detection of vascular endothelium-dependent relaxing reaction, observation of lovastatin HTL induced endothelial function injury protection role.Results Given different concentration of lovastatin （10, 20, 40 μmol/L） can significantly improve the HTL damage of vascular ring EDR, compared with HTL injury group had significant difference （P〈 0.05 orP 〈 0.01）.ConclusionsLovastatin showed a concentration dependent antagonism of HTL damage effects on endothelial function, its mechanism may be related to the inhibition of oxidative stress, protecting vascular endothelial NO synthesis and release of.

关 键 词：洛伐他汀 内皮依赖性舒张反应 HTL 

分 类 号：R453[医药卫生—治疗学]