不同灭菌方法对脂宁口服液中有效成分含量的影响  

Effect of different sterilization on contents of effective components in Zhining Oral Solution

作　　者：李顺祥[1] 谢昭明[1] 朱如彩[1] 

机构地区：[1]湖南省中医药研究院中药研究所,湖南长沙410013

出　　处：《中成药》2002年第7期511-513,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :研究脂宁口服液的最佳灭菌方法。方法 :采用高效液相色谱法测定不同灭菌方法处理的脂宁口服液中有效成分 2 ,3,5 ,4′ 四羟基二苯乙烯苷、大黄酚的含量。结果 :巴氏灭菌法和 10 0°C流通蒸汽灭菌法对脂宁口服液中所含主要有效成分含量的影响很小 ,而 12 6°C热压灭菌法、60 Co辐照灭菌法分别降低该制剂中大黄酚、四羟基二苯乙烯苷的含量。结论 :不同灭菌方法对制剂所含成分有不同影响 ;Objective:To find a suitable sterilization for the Zhining oral solution. Methods:The contents of effective components in Zhining oral solution with the different sterilizations were determined by HPLC.Results: Pasteurization and flowsteam sterilization have little effect on the contents of effective components in Zhining oral solution, while autoclave sterilization and 60 Co radiation sterilization reduced respectively the contents chrysophanol or 2,3,5,4′ tetrahydroxystilbene 2 O β D glucoside. Conclusions: The different sterilizations have different effects on contents of effective components. Zhining oral solution should be sterilized by pasteurization.

关 键 词：灭菌方法 脂宁口服液 大黄酚 2 3 5 4'-四羟基二苯乙烯苷 含量测定 高效液相色谱法 

分 类 号：R286.0[医药卫生—中药学]