热灌注化疗与传统化疗灌注栓塞治疗原发性肝癌的临床应用  

Clinical study of traditional chemo-embolization combined with hermal-chemotherapy infusion in patients with primary liver cancer

作　　者：许峰[1] 鲍君杰[1] 吴铭生[2] 

机构地区：[1]苏州大学附属第二医院药剂科,江苏苏州215004 [2]山东大学,山东济南250000

出　　处：《中国生化药物杂志》2015年第2期143-145,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：山东省自然科学基金(Y2008C105)

摘　　要：目的 比较热灌注化疗与传统的化疗灌注栓塞治疗原发性肝癌的临床疗效.方法 选取2011年1月～2013年12月苏州大学附属第二医院100例原发性肝癌患者,按照随机数表法分为观察组和对照组,每组各50例.观察组采用热灌注化疗,对照组采用传统化疗.比较治疗前与治疗后3、30d 2组患者肝功能、肾功能变化及疗效.结果 常规复查肝功能结果显示,2组患者的丙氨酸转氨酶（ALT）及天冬氨酸转氨酶（AST）水平在治疗前差异无统计学意义;治疗3d后,2组患者ALT和AST水平较治疗前均有不同程度的升高,且观察组显著低于对照组（P＜0.01）;治疗后30 d,2组患者的ALT和AST水平恢复到治疗前水平,但组间比较差异无统计学意义.常规复查肾功能结果显示,与治疗前相比,治疗3、30 d后2组患者血尿素氮（BUN）和血肌酐（Crea）水平差异均无统计学意义.观察组临床有效率达到76.00％,显著高于对照组的32.00％,2组比较差异有统计学意义（P＜0.01）.结论 与传统的化疗灌注栓塞相比,热灌注化疗治疗临床有效率高,疗效好,且对患者肝、肾功能影响较小,有益于提高患者的生存质量,为进一步研究原发性肝癌的治疗方法提供临床依据.Objective To compare clinical efficacy of hermal-chemotherapy infusion and traditional chemo-embolization in treatment of primary liver cancer. Methods 100 cases with primary liver cancer from January 2011 to December 2013 were randomly divided into observation group（ n = 50） and control group （ n = 50） with random number table, observation group were treated with hermal-chemotherapy infusion, and control group were treated with traditional chemo-embolization. Liver function, renal function changes and clinical efficacy were compared between two groups before and after 3, 30days＇ treatment. Results Liver function result showed alanine aminotransferase （ALT） and aspartate aminotransferase （AST） levels were compared between two groups with no significant difference before treatment; after 3days＇ treatment, ALT and AST levels elevated compared with before treatment in two groups at different degree, and the above indexes in observation group were significantly lower than those in control group, with significant difference（P 〈0. 01 ） ; after 30 days＇ treatment, ALT and ASP levels in two groups returned to pretreatment levels, and the above indexes were compared between two groups with no significant difference. Renal function result showed, urea nitrogen（BUN） and serum ereatinine （Crea）levels after 3 days＇, 30 days＇ treatment were compared with before treatment in two groups with no significant difference. The clinical efficiency of observation group was 76. 00% , which was significantly higher than 32.00% of control group, and there was significant difference between the two groups （P 〈 0. 01 ）. Conclusion Compared with the traditional chemo-embolization, hermal-chemotherapy infusion in the treatment of primary liver cancer has a better effective rate, and less influence on the liver and kidney function of the patients, and is beneficial for patients to improve the living quality, which provides the clinical evidences for further study of the therapy of primary liver can

关 键 词：原发性肝癌 热灌注化疗 化疗栓塞 

分 类 号：R453[医药卫生—治疗学]