蒿白伤湿气雾剂对大鼠佐剂性关节炎的效果观察  

Efficacy of Artemisia stelleriana Bess. dampness damage aerosol in rats with adjuvant arthritis

作　　者：翦林宏[1] 肖梅英[1] 李勇敏[1] 

机构地区：[1]湖南省中医药研究院,湖南长沙410006

出　　处：《湖南中医杂志》2015年第4期168-170,共3页Hunan Journal of Traditional Chinese Medicine

摘　　要：目的:观察蒿白伤湿气雾剂治疗大鼠佐剂性关节炎的效果。方法:将60只SD雄性大鼠随机分为空白对照组,模型对照组,风湿跌打组及蒿白伤湿气雾剂低、中、高剂量组,对除空白组外的其余组大鼠左、右后趾皮下注射弗氏完全佐剂致炎,致炎后分别将治疗药物涂于足部与腹部,连续27d,观察各组大鼠继发性炎症,测肿胀率。结果:蒿白伤湿气雾剂能明显改善佐剂性关节炎大鼠耳部红斑、尾部结节发生率及严重程度,对佐剂性关节炎大鼠继发性病变有一定的改善作用;能降低佐剂性关节炎大鼠左右后足趾肿胀率,对佐剂性关节炎大鼠关节病变有较好的治疗作用。结论:蒿白伤湿气雾剂对大鼠佐剂性关节炎有较好的防治作用。Objective： To observe the efficacy of Artemisia stelleriana Bess. dampness damage aerosol in rats with adjuvant arthritis. Methods ： Sixty male Sprague - Dawley rats were randomly divided into blank control group, model control group, wind -damp dieda group, and low -, medium -, and high -close Artemisia stelleriana Bess. dampness damage aerosol groups. Rats in all groups except the blank control group were subcutaneously injec- ted with Freund complete adjuvant into the right and left hind paws to induce inflammation. Afterwards, therapeutic ously for 27days. Secondary inflammation was observed and swelling rate was measured in the rats of each group. Results： Artemisia stelleriana Bess. dampness damage aerosol significantly reduced the incidence rate and se- verity of erythema of the ears and tubercles of the tails adjuvant arthritis. Artemisia stelleriana Bess. dampness and, to some extent, improved damage aerosol also reduced and left hind paws and had a better therapeutic effect on lesions in rats with adjuvant ia stelleriana Bess. dampness damage aerosol has good efficacy in the prevention and in rats. secondary lesions in rats with the swelling rates of the right arthritis. Conclusion ： Artemis- treatment of adjuvant arthritis in rats.

关 键 词：蒿白伤湿气雾剂 佐剂性关节炎 继发性炎症 肿胀率 实验研究 

分 类 号：R285.5[医药卫生—中药学]