丹参川芎嗪对老年急性心肌梗死患者炎症因子及血管内皮功能的影响  

Effect of Salvia Tetramethylpyrazine injection on circulation inflammatory cytokines and vascular endothelial function in patients with acute myocardial infarction

作　　者：可海霞[1] 张金盈[1] 贾银明[3] 王会玖[2] 张海柱[2] 刘谨春 

机构地区：[1]郑州大学第一附属医院心内科,河南郑州450052 [2]安阳市人民医院心内科,河南安阳455000 [3]安阳市中医院心内科,河南安阳455000

出　　处：《中国急救医学》2015年第5期430-432,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的：观察丹参川芎嗪注射液对老年急性心肌梗死（ AMI）患者炎症因子及血管内皮功能的影响。方法检测100例老年AMI患者及30例健康对照者的血清高敏C－反应蛋白（hs－CRP）、白细胞计数（WBC）、白细胞介素－6（IL－6）、一氧化氮（NO）和内皮素－1（ET－1）的浓度。老年AMI患者被随机分为丹参川芎嗪治疗组50例和常规治疗组50例。测定治疗前、治疗2周后外周血清hs－CRP、WBC、IL－6、NO和ET－1浓度。结果 AMI患者治疗前血清hs－CRP、WBC、IL－6和ET－1浓度均高于健康对照组（P＜0．01），而NO水平明显低于健康对照组（P＜0．01）；两组患者治疗前各指标比较差异均无统计学意义（P＞0．05）。两组患者治疗2周后血清hs－CRP、WBC、IL－6和ET－1浓度明显低于治疗前（P＜0．01），但丹参川芎嗪治疗组较常规治疗组下降更明显（P＜0．05）；血清NO浓度则较治疗前升高（P＜0．01），但丹参川芎嗪组较常规治疗组升高更明显（P＜0．05）。结论老年AMI患者炎症因子明显升高，存在严重的内皮功能障碍。丹参川芎嗪注射液可降低老年AMI患者血清炎症因子的浓度，改善血管内皮功能。hs－CRP、WBC和IL－6可作为观察老年AMI患者病情预后及疗效评价的指标。 NO和ET－1可作为观察老年AMI患者血管内皮功能障碍的灵敏指标。Objective To investigate the changes of inflammatory cytokines and vascular endothelial function related factors in patients with acute myocardial infarction （ AMI ） and the therapeutic effects of Salvia Tetramethylpyrazine injection.Methods One hundred AMI patients were selected and randomly divided into routine group and Salvia Tetramethylpyrazine group.Thirty healthy people served as control group.The levels of high sensitivity C-reactive protein （ hs-CRP ） , white blood cell count （WBC）, interleukin-6 （IL-6）, and nitrogen monoxide （NO） and endothelin-1 （ ET-1） were measured respectively before and after treatment.Results All AMI patients showed that the serum concentrations of hs-CRP, IL-6, WBC and ET-1 were apparently higher than those in healthy subjects （P〈0.01）, and the NO level in AMI patients was lower than that in healthy subjects （P〈0.01）.The levels of hs-CRP, IL-6, WBC and ET-1 decreased significantly after two week treatment （P〈0.01）.The decreased level of these parameters in the Salvia Tetramethylpyrazine group were greater than routine group （P〈0.05）.The level of NO in the Salvia Tetramethylpyrazine group was increased more significantly than that of routine group （ P 〈0.05 ） .Conclusion The changes concentrations of hs-CRP, IL-6, WBC, ET-1 and NO can be used as sensitive indexes for dynamic prognosis AMI.Salvia Tetramethylpyrazine injection may decrease the level of hs-CRP, WBC, IL-6 and elevate the level of NO.The results suggest that Salvia Tetramethylpyrazine injection may have an anti-inflammatory role and improve vascular endothelial function in treatment AMI patients.

关 键 词：急性心肌梗死( AMI) 丹参川芎嗪注射液 血管内皮功能 炎症因子 老年 

分 类 号：R542.22[医药卫生—心血管疾病]