小剂量多巴胺联合酚妥拉明治疗原发性肾病综合征中重度水肿  

Treatment of primary nephrotic syndrome in children with severe edema by phentolamine associated with low-dose dopamine

作　　者：银宏伟 

机构地区：[1]河南省原阳县红十字医院,453500

出　　处：《中国实用医刊》2015年第10期24-25,共2页Chinese Journal of Practical Medicine

摘　　要：目的 探讨小剂量多巴胺联合酚妥拉明对原发性肾病综合征中重度水肿的临床疗效.方法 将100例原发性肾病综合征患者随机分为观察组和对照组,每组50例,观察组采用小剂量多巴胺与酚妥拉明联合治疗,对照组采用呋塞米治疗,观察对比两组患者尿量、水肿消退程度、消退时间及不良反应发生率.结果 观察组尿量显著多于对照组,患儿水肿的消退时间显著短于对照组,不良反应发生率显著低于对照组,两组比较差异有统计学意义（P＜0.05）.结论 采用小剂量多巴胺联合酚妥拉明治疗原发性肾病综合征患儿中重度水肿可增加尿量,迅速消肿且不良反应小,临床效果良好,值得临床推广应用.Objective To investigate the clinical effects of application of low-dose dopamine combined with phentolamine on primary nephritic syndrome in children with severe edema.Methods One hundred cases of children with primary nephrotic syndrome were randomly divided into observation group and control group,with 50 cases in each group,low-dose dopamine combined phentolamine treatment were used in the observation group; furosemide was used in the control group.The urine volume,edema subsided,fade time and incidence of adverse reactions of the two groups were compared.Results Urine of children in the observation group was significantly higher than that in the control group,edema subsided significantly shorter than that in the control group,the incidence of adverse events was significantly lower than that in the control group,the differences between the two groups were statistically significant （P 〈 0.05）.Conclusions Treatment of primary nephrotic syndrome in children with severe edema by phentolamine associated with low-dose dopamine,can increase urine volume,rapidly swelled and with low side effect,the clinical results are good,should be widely applied.

关 键 词：原发性肾病综合征 多巴胺 酚妥拉明 水肿 

分 类 号：R692[医药卫生—泌尿科学]