竹节人参提取物对胃缺血再灌注损伤的防护  

Effect of Panan Japonicus in Protecting Gastric Ischemia -Reperfusion Injury

作　　者：刘红[1] 

机构地区：[1]湖北民族学院医学院,湖北恩施445000

出　　处：《湖北民族学院学报（医学版）》2002年第2期1-3,共3页Journal of Hubei Minzu University(Medical Edition)

摘　　要：目的　观察竹节人参提取物对胃缺血再灌注损伤的防护作用。方法 采用腹腔动脉结扎法,造成胃缺血20min,解除结扎,再灌注60min后,取出胃粘膜,观察正常对照组,病理模型组和用药各组中胃粘膜之氧自由基、脂质过氧化物及清除酶系诸指标的变化。结果 大鼠胃缺血后再灌注,胃粘膜脂质过氧化物（LPO）含量比正常对照组明显增加,超氧化物歧化酶（SOD）,谷脱甘肽过氧化物酶（GSH-Px）含量则明显降低（P<0.01）:术前口服竹节人参提取物组,胃粘膜LPO含量明显低于病理组,SOD、GSH-Px水平则明显高于病理组（P<0.01）。结论 竹节人参提取物通过消除和抑制胃缺血再灌注时氧自由基产生,提高组织抗氧化能力,对胃缺血再灌注损伤起到保护作用。Objective To observe the effect of Panax Japonicus in Protecting gastric Ischemi-a -Reperfusion injury. Methods The gastic mucosa injury was produced in rats by applying a small clamp to the celiac artery for 20min and removed the clamp for 60min, then the rats were killed, the gastric mucosa removed and SOD, LPO, GSH -Px, PGE2 of the mucosa in control group, treated group and pathologic model group were detected. Results LPO level of gastric mucosa in treated group was significantly higher, SOD, GSH - Px level were lower than those in control group (P <0. 01) . LPO levels of gastric mucosa in rats given Panax Japonicus were greatly lower than that of the I-R group. SOD, GSH -Px levels were obviously higher than those in treated group(P <0. 01) while LPO level of gastric mucosa, SOD and GSH -Px levels in trated group were significantly higher than in pathologic model group(P <0. 01). Conclusion Panax Japonicus could protect the gastric ischemia -reperfusion injury by eliminating and in-hibiting production of Oxygen free radical during gastric ischemia-reperfusion and thus en-hancing the anti -oxidizing ability of tissues.

关 键 词：竹节人参提取物 胃缺血再灌注 胃粘膜损害 动物模型 腹腔动脉结扎法 

分 类 号：R282.710.5[医药卫生—中药学]