氨曲南致不良反应65例文献分析  

Analysis on 65 Reports of Aztreonam ADR

作　　者：陈华彪[1] 刘兰侠[1] 刘莉[1] 

机构地区：[1]蚌埠市第一人民医院药剂科,安徽蚌埠233000

出　　处：《中国药房》2015年第14期1956-1958,共3页China Pharmacy

摘　　要：目的：为医疗机构安全使用氨曲南提供参考。方法：检索维普期刊全文数据库2004-2014年收录的氨曲南ADR文献57篇,共65例,采用Excel进行统计,其内容包括发生ADR患者的年龄与性别、用法用量、ADR发生的时间、过敏史、ADR类型及临床表现等,并加以分析。结果：65例氨曲南ADR中,性别差异无统计学意义（P〉0.05）,21~45岁中青年患者居多（49.23%）;患者临床表现多种多样,累及人体多个器官/系统;53.85%的ADR发生于用药30 min之内;ADR以过敏反应为主,严重的可致过敏性休克,其他还有单纯皮肤反应、神经系统反应、白细胞计数减少、心律不齐及肝功能损害等。结论：临床使用氨曲南,应首先询问患者过敏史,使用中多观察、多巡视,并做好ADR的对症处理及抢救工作。OBJECTIVE： To provide reference for the safe use of aztreonam in medical institutions. METHOD： 65 reports of aztreonam ADR in VIP Database from 2004 to 2014 were collected and analyzed, including the age, gender, usage and dosage, occurrence time and types of ADR, clinical manifestations and allergies history. RESULTS： There was no significant difference in the gender among the 65 reports of aztreonam ADR （P〉0.05） and there were mainly young and middle-aged patients （49.23%） in the 21-45 years. There were numerous types of aztreonam＇ s ADR clinical manifestations, involving many human organs and tissues. 53.84% of ADR occurred within 30 minutes of medication. Most ADR was allergic reaction, the severe one was allergic shock; there were other ADR, including nervous system reaction, leukopenia, arrhythmias and liver dysfunction, etc. CONCLU- SIONS： When using aztreonam in clinic, allergic history should firstly be consulted, observation and inspection are necessary; meanwhile, symptomatic treatment and rescue work should be prepared.

关 键 词：氨曲南 药品不良反应 文献 分析 

分 类 号：R969.3[医药卫生—药理学] R978.11[医药卫生—药学]