经典抗菌药氯碘羟喹抗癌机制的研究进展  

Research progress of anticancer mechanism of the classic antibacterial medicines clioquinol

作　　者：李凯舒 何明亮[1] 皮荣标[2] 刘安民[1] 

机构地区：[1]中山大学孙逸仙纪念医院神经外科,广东510120 [2]中山大学药学院药理学与毒理学实验室,广东510006

出　　处：《中国新药杂志》2015年第9期1002-1006,共5页Chinese Journal of New Drugs

基　　金：国家自然科学基金(31371070);广东省自然科学基金(S2011010002638);广东省科技计划项目(2012B031800356)

摘　　要：氯碘羟喹从1934年开始作为一种口服抗菌药广泛应用于胃肠道感染性疾病,后来因为发现其能诱发亚急性脊髓视神经病而被限制使用。2005年开始,陆续有研究报道,氯碘羟喹具有诱导癌细胞凋亡的作用,随后针对氯碘羟喹抗癌作用机制的一系列研究逐渐开展,并证实其能作为铜、锌等金属离子载体,通过多种细胞通路诱导癌细胞的凋亡,因此氯碘羟喹抗癌作用的研究得到重视。本文就氯碘羟喹抗癌机制的研究进展做一综述。Clioquinol （CQ） , an oral antibacterial medicine, had being used to treat a wide range of intes- tinal diseases since 1934. However, it was limited fnr using as an oral agent after the researchers found its associa- tion with subacute myelooptic neuropathy （SMON）. Since 2005, CQ had been reported to induce apoptosis of cancer cells. Then a series of studies on the anticancer mechanism of CQ were performed gradually, and it was con- firmed that CQ can be used as copper, zinc and other metal ion carriers amt induce apoptosis of cancer cells through a variety of cellular pathways. Thereby, the anticancer mechanism of CQ has been focused. This article will summarize the research progress of its anticancer mechanism.

关 键 词：氯碘羟喹 癌细胞 离子载体 凋亡 

分 类 号：R979.14[医药卫生—药品]