新生化颗粒联合米非司酮配伍米索前列醇对孕14～26周中期引产的效果评价  

Effect assessment of new biochemical particles combined with mifepristone and misoprostol for induced labor in the medium term pregnancy of 14～26 weeks

作　　者：单龙[1] 刘燕[1] 段丽君[1] 孙晓彤[1] 黄丽辉[1] 罗亚莉[1] 

机构地区：[1]甘肃省人民医院产科,甘肃兰州730030

出　　处：《中国计划生育和妇产科》2015年第5期59-63,共5页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的对新生化颗粒联合米非司酮配伍米索前列醇对14-26周中期妊娠引产的效果进行分析评价。方法选取2010-2013年间甘肃省人民医院240例孕14~26周要求终止妊娠妇女的资料,按不同的引产和给药方式分为A、B、C、D四组,每组各60例。A组：口服米非司酮100 mg×2 d,第3天阴道放置及舌下含化米索前列醇各200μg,1次/3 h,期间冲服新生化颗粒2袋/次,3次/d至产后3 d;B组：首日顿服米非司酮200 mg,其余同A组;C组：首日顿服米非司酮200 mg,第3天晨阴道放置米索前列醇400μg,随后每隔3 h口服400μg,最多4次;D组：常规依沙丫啶羊膜腔穿刺注射引产术。比较4组引产成功率、不良反应发生率、引产时间、阴道出血量、月经复潮时间等指标。结果 4组引产方式总成功率分别为98.3%、96.7%、96.7%、95.0%,差异无统计学意义（P〉0.05）。C组不良反应发生率最高,A组恶心呕吐发生率（1.7%）低于B组（11.7%）,D组疼痛率最高（45%）（P〈0.05）。A、B组米索前列醇用量、引产时间、阴道出血量低于C组（P〈0.05）,D组引产时间最长,阴道出血量最多（P〈0.05）。结论米非司酮分次口服配伍米索前列醇舌下、阴道联合给药,同时辅以新生化颗粒冲服的引产方法,引产时间更短,米索前列醇用量、阴道出血、疼痛率及不良反应更少。Objective To analyze the effect of new biological particles combined with mifepristone and misoprostol for induced labor in the medium term pregnancy for 14 - 26 weeks. Methods Clinical data of 240 women required to terminate pregnancy during 14 - 26 weeks in People＇s Hospital of Gansu Province from 2010 to 2013 were collected. All cases were divided into A, B, C, D groups with 60 cases in each group according to different induced labor ways and methods of administration. Group A ： Oral administration of mifepristone 100 mg × 2 d, vaginal placed and sublingual dehvery of misoprostol 200 Ixg respectively in 3 days, 1 time/3 h, oral administration of dissolved new biological particles 2 bags/time, 3 times/d. Group B ： Oral administration of 200 mg mifepristone onthe first day, the other treatments were the same as group A. Group C ： Oral administration of 200 mg mifepristone on the first day, vaginal placed 400 I＊g in 3 days, followed by 0.4 mg of misoprostol administered orally every 3 h （4 times in maximum）. Group D： Amniotic cavity injection of rivanol. The total success rates, adverse reactions rates, induced labor time, hemorrhage amount, menstruation after tide time, et al were compared between 4 groups. Results The total success rates of four groups were 98.3 %, 96.7 % , 96. 7 %, 95.0 % , there was no statistically significant difference （P 〈 O. 05）. The adverse reactions rates in Group C was the highest, the incidence of nausea and vomiting in group A（ 1.7 % ） was lower than that in group B（ 11.7 % ） （P 〈0. 05）, the pain rate in group D was highest （45 % ） （ P 〈 O. 05 ）. Dosage of misoprostol, induced labor time, hemorrhage amount in group A and group B were lower than that in group C （ P 〈 0.05 ）, cases in group D had the longest induced labor time, the largest hemorrhage amount, the latest menstruation after tide time. Conclusion By oral administration of mifepristone combined with sublingual and vaginal misoprostol, supplemented by oral administration

关 键 词：新生化颗粒 米非司酮 米索前列醇 中期引产 

分 类 号：R719.3[医药卫生—妇产科学] R979.2[医药卫生—临床医学]