补肾益胎汤联合黄体酮对早期先兆流产患者血清孕酮及β-绒毛膜促性腺激素水平的影响  

Effects ofBushen-Yitai powder combined with progesterone on patients with early threatened abortion progesterone andβ-HCG levels

作　　者：董玉霞[1] 闫宝环[2] 王艳[3] 王建玲[1] 王翠霞[1] 

机构地区：[1] 河北省胸科医院妇产科,石家庄050041 [2] 河北省胸科医院中医科,石家庄050041 [3] 河北省胸科医院儿科,石家庄050041

出　　处：《国际中医中药杂志》2015年第5期409-412,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的：探讨补肾益胎汤联合黄体酮对早期先兆流产患者血清孕酮及β-绒毛膜促性腺激素（β-human chorionic gonadotropin,β-HCG）水平的影响。方法本研究为随机对照研究。将符合纳入标准的96例早期先兆流产患者采用随机数字表法按1︰1的比例随机分为2组各48例。对照组肌肉注射黄体酮，20 mg，3次/周；治疗组在对照组治疗基础上服用自拟补肾益胎汤，1剂/d。2组均治疗7 d为1个疗程，共治疗2个疗程。治疗后检测2组血清孕酮和β-HCG水平，并评价其临床疗效。结果治疗组和对照组总有效率分别为93.7%（45/48）和79.2%（35/48），2组比较差异有统计学意义（χ2＝4.360，P＝0.037）。治疗组治疗后血清β-HCG[（38.37±5.66）ng/ml比（30.63±3.86）ng/ml，t＝7.827]、孕酮[（17645.40±2483.11）U/L比（15442.24±1633.16）U/L，t＝5.136]水平升高情况均优于对照组（P均＜0.01）。治疗组治疗后出血时间[（1.52±0.31）分比（2.01±0.35）分，t＝7.261]、出血量[（1.41±0.33）分比（1.89±0.26）分，t＝7.916]、腰酸胀痛[（1.33±0.30）分比（1.98±0.25）分，t＝6.464]、小腹疼痛或坠胀[（1.43±0.33）分比（1.79±0.20）分， t＝11.532]评分均较对照组下降（P＜0.01）。结论补肾益胎汤辅助黄体酮可提高早期先兆流产患者的临床疗效。Objective To investigate the effects of Bushen-Yitai powder combined with progesterone on serum levels of progesterone and β-humun chorionic gonadotropin （β-HCG） in patients with early threatened abortion. Methods A total of 96 patients with early threatened abortion were randomly divided into a control group and a treatment group by random number table method, with 48 patients in each group. The patients in the control group received injection of progesterone, 20 mg, 3/week. The patients in the treatment group were treated with Bushen-Yitai powder, 1 agent/d on the basis of the control group. Both groups were treated for 14 days. At the end of treatment, the serum levels of progesterone and β-HCG were detected, and the clinical efficacy was evaluated. Results The total effective rates in the treatment and control groups were 93.7% and 79.2%, respectively, with statistical difference （2,2=4.360, P=0.037）. After the treatment, the serum levels of β-HCG （38.37 ± 5.66 ng/ml vs. 30.63 ± 3.86 ng/ml, t=7.827） and progesterone （17 645.40 ± 2 483.11 U/L vs. 15 442.24 ± 1 633.16 U/L, t= 5.136） in the treatment group were significant higher than those in the control group. The scores of bleeding time （1.52 ± 0.31 vs. 2.01± 0.35, t=7.261）, bleeding amount （1.41 ± 0.33 vs.1.89± 0.26, t=7.916）, backache pain （1.33±0.30 vs.l.98± 0.25, t=6.464）, abdominal pain and distension （1.43 ± 0.33 vs.l.79 ±0.20, t=11.532） in the treatment group were significant lower than those in the control group（P〈0.01）.Conclusion Bushen-Yitai powder adjuvant to progesterone therapy can improve the clinical outcome in patients with early threatened abortion.

关 键 词：流产 先兆 孕酮 绒毛膜促性腺激素 β亚单位 人 补肾益胎汤 

分 类 号：R714.21[医药卫生—妇产科学]