大豆苷及大豆苷元溶解吸收特性差异比较及相互作用研究  

The solubility, permeability and their interaction of daidzin and daidzein

作　　者：董红环[1] 潘艳丽[2] 刘洋[1] 张雷[1] 马晓云[1] 罗志强[1] 杨立媛 杨瑞瑞[1] 

机构地区：[1] 北京中医药大学中药学院,100102 [2] 中国中医科学院中医药信息研究所所办公室,北京100700

出　　处：《国际中医中药杂志》2015年第5期439-442,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的：考察大豆苷和大豆苷元的溶解吸收特性及两者共存条件下在溶解和吸收方面的相互影响。方法采用溶解度实验技术测定大豆苷和大豆苷元的平衡溶解度；采用大鼠在体单向肠灌流方法研究大豆苷元和大豆苷肠渗透性相互作用。结果在pH＝7.4的K-R试液中，大豆苷的溶解度约为大豆苷元的6倍，两者共存时溶解度均有所增强。大豆苷元在大鼠肠道内的吸收系数约为大豆苷的3倍，大豆苷对大豆苷元的吸收有显著性增强作用，但大豆苷元对大豆苷的吸收有抑制作用。结论大豆苷元的溶解度低于大豆苷，渗透性高于大豆苷。两者合用后大豆苷元的溶解度和渗透性均明显增强，大豆苷的溶解度增强不显著，且渗透性显著降低。Objective The alm of this study was to determine the solubility and permeability of daldzin and daldzein and the interaction of these two components.Methods With the method inChinese Pharmacopoeia and in situ single-pass intestinal perfusion model we tested the solubility and permeability of daldzin, daldzein and their interaction.Results In pH 7.4 K-R buffer the solubility of daldzin was 6 times than daldzein and both the solubility of these two components were enhanced when they were determined together. In small intestine of rat, the permeability of daldzein was 3 times than daldzin. Daldzin could enhance the permeability of daldzein but the daldzein manifested an opposite trend.Conclusion When compared to daldzin, daldzein owned a lower solubility but a better permeability. When used together, both the solubility and permeability of daldzein would be enhanced. The solubility of daldzin could be enhanced slightly but its permeability would be reduced.

关 键 词：大豆苷元 大豆苷 溶解度 渗透性 相互作用 

分 类 号：R284[医药卫生—中药学] R285.5[医药卫生—中医学]