间充质干细胞来源微粒及其在肺脏疾病中的研究进展  

Advances in microvesicles derived from mesenchymal stem cells in lung diseases

作　　者：陈洁[1] 陈良安[1] 

机构地区：[1]解放军总医院呼吸科,北京100853

出　　处：《国际呼吸杂志》2015年第8期633-636,共4页International Journal of Respiration

基　　金：军队临床高新技术重大项目（2010gxjs090）

摘　　要：间充质干细胞来源的微粒是间充质干细胞在静息或活化状态下释放到细胞外基质中直径30～1 000 nm的膜性小囊泡.最近的研究发现干细胞来源的微粒可以有效地转运mRNA、miRNA和蛋白质等生物活性物质,在调控组织再生修复方面发挥重要作用.本文综述干细胞微粒的形成机制、生物学特性及在肺脏疾病中主要作用的研究进展,为干细胞肺组织修复机制研究提供新的思路.Microvesicles derived from mesenchymal stem cells have a diameter of 30-1000 nm and are small membrane vesicles generated by mesenchymal stem cells in resting or activated state.Recent studies have found that microvesicles secreted by stem cells can effectively transport biological active substances such as mRNA,microRNA,and proteins,and play an important role in regulating tissue regeneration.Here we give an overview of formation mechanisms,biological properties,and their roles in lung diseases in order to provide some novel information to highlight the stem cells therapy in lung diseases.

关 键 词：间充质干细胞 微粒 肺脏疾病 

分 类 号：R563[医药卫生—呼吸系统]