ICU铜绿假单胞菌临床分布及耐药性分析  

Analysis of clinical distribution and drug resistance of Pseudomonas aeruginosa in ICU

作　　者：姜文[1] 杨海卫[1] 孙强[1] 董方[1] 马振[1] 

机构地区：[1]济宁医学院附属医院ICU一区,272029

出　　处：《国际呼吸杂志》2015年第9期691-693,共3页International Journal of Respiration

摘　　要：目的调查ICU铜绿假单胞菌临床分布及耐药性分析，为临床诊断及合理应用抗生素提供科学依据。方法选择济宁医学院附属医院ICU一区2013年9月至2014年9月住院患者的临床标本进行常规细菌培养鉴定，以K—B纸片扩散法进行药物敏感性试验，对分离出的铜绿假单胞菌药敏试验结果进行统计分析。结果从各种标本中共分离到铜绿假单胞菌216株，其中呼吸道标本痰液百分比最高，占69％。在15种抗生素药敏试验中阿米卡星、头孢哌酮舒巴坦钠、头孢吡肟体外抗菌活性最好，铜绿假单胞菌株耐药性强，产生多重耐药菌63株。结论ICU铜绿假单胞菌感染主要为呼吸道感染，ICU中铜绿假单胞菌耐药率较高，应引起高度重视，要加强病原学检测，以有效控制感染。Objective To investigate the clinical distribution and drug resistance of Pseudomonas aeruginosa in intensive care units （ICU）, and provide scientific basis for the clinical diagnosis and reasonable application of antibiotics. Methods Clinical specimens which were recruited from I in the Affiliated Hospital of Jining Medical College from September 2013 to September 2014. They were treated with routine bacterial culture and identification. Drug susceptibility test was performed by K-B disk diffusion method. The statistical analysis was carried on the separated Pseudomonas aeruginosa susceptibility test results. Results Two hundred and sixteen strains of Pseudomonas aeruginosa were isolated from the various specimens, among which the respiratory tract sputum percentage was the highest, accounting for 69 %. Among 15 kinds＇ antibiotic susceptibility tests, the vitro antibacterial activity of Amikacin,cefoperazone sulbactam sodium and cefepime were the best. Pseudomonas aeruginosa strain resistance was strong. Sixty-three multi drug resistant bacteria strains were produced. Conclusions The infection of Pseudomonas aeruginosa in ICU is mainly through respiratory tract. The resistance rate of Pseudomonas aeruginosa is high in ICU, which should be paid great attention to. We should do more pathogen detections to control the infection effectively.

关 键 词：重症监护病房 铜绿假单胞菌 耐药性 

分 类 号：R446.5[医药卫生—诊断学]