呼出气一氧化氮检测在儿童呼吸系统疾病的临床应用  

The clinical application of exhaled nitric oxide measurement in pediatric lung diseases

作　　者：张倩[1] 孙中厚[1] 

机构地区：[1]潍坊医学院附属医院儿一科,261031

出　　处：《国际呼吸杂志》2015年第9期717-720,共4页International Journal of Respiration

摘　　要：一氧化氮作为非肾上腺能、非胆碱能神经的神经递质，可作用于血管并参与调节支气管平滑肌的功能。自从1993年Alving等首次发现呼出气一氧化氮（FeNO）在哮喘患者中明显升高，就开始了对FeNO的广泛研究。FeNO测定作为一种评估伴有呼吸系统疾病的儿童气道炎症水平的非侵入性方法，目前已广泛应用于儿童哮喘的管理中。很多方法可以检测FeNO水平，尽管很多因素可以影响检测结果，但似乎它比肺功能及支气管激发试验有更高的准确性。目前FeNO在慢性咳嗽、ARDS、鼻炎、病毒性细支气管炎、社区获得性肺炎、支气管扩张、闭塞性细支气管炎及弥漫性肺疾病等儿童呼吸系统疾病的诊断、治疗及评估预后中也有很大的意义。As an neurotransmitter of non-adrenergic and non-cholinergic nerve,nitric oxide can act on blood vessels and involve in the regulation of bronchial smooth muscle function. Since Alving had firstly found in 1993 that exhaled nitric oxide （FeNO） significantly increased in asthma patients, extensive study of FeNO present. As an non-invasive method,FeNO can be used to evaluate the airway inflammation of children who has respiratory disease and has been widely used in the management of childhood asthma. Many methods can detect FeNO levels, although many factors can affect the test results, hut the FeNO seems to have a higher accuracy than pulmonary function and bronchial provocation tests. Currently FeNO also has great significance in the diagnosis,treatment and evaluation of prognosis of children＇s respiratory disease such as chronic cough, acute respiratory distress syndrome, rhinitis, viral bronehiolitis, community acquired pneumonia, bronchiectasis, bronchiolitis obliterans and diffuse lung diseases.

关 键 词：呼出气一氧化氮 气道疾病 儿童 

分 类 号：R725.6[医药卫生—儿科]