缺氧诱导因子-1α与糖尿病血管新生的研究进展  

Advance on the relationship between HIF-1α and angiogenesis deficiency in diabetes

作　　者：艾丽根[1] 刘芳[1] 

机构地区：[1]上海交通大学附属第六人民医院内分泌代谢科,上海市糖尿病临床医学中心,上海市重中之重代谢病临床医学中心,上海市糖尿病研究所,上海市糖尿病重点实验室,200233

出　　处：《中国糖尿病杂志》2015年第5期470-474,共5页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81270397)

摘　　要：缺氧诱导因子-1α(HIF-1α)是与氧气内环境有关的关键转录因子,其调控缺氧引起的多种细胞适应性反应,如血管新生、新陈代谢以及细胞凋亡等。肥胖时,脂肪组织功能紊乱与IR成对出现,形成局部缺氧,出现血管新生障碍。相似的,T2DM可引起组织局部缺氧及HIF-1α的产生受到抑制,血管新生因子下调,最终引起多种血管并发症。同时,异常表达的微小RNA(microRNAs)对HIF-1α的表达及其功能有着极为重要的作用。HIF-1α在血管新生、伤口愈合等方面起重要作用。HIF-1α可结合缺氧反应元件,调节VEGF的表达,进而促进血管新生。本文就HIF-1α及其对糖尿病血管新生的影响做一综述。Hypoxia induced‐factor 1α（HIF‐1α） is a critical transcription factor involved in oxygen homeostasis which regulates a variety of cellular adaptive responses to hypoxia ,including angiogenesis , metabolism ,and apoptosis .In obesity ,adipose tissue dysfunction coupled with insulin resistance results in local hypoxia and angiogenesis disorders .Similarly ,type 2 diabetes （T2DM ） may present with chronic hypoxia ,inhibition of HIF‐1αproduction ,down‐regulation of angiogenesis factors ,and eventually cause a variety of vascular complications .Meanwhile ,the abnormal expression of microRNAs could affect the expression and function of HIF‐1α.HIF‐1α plays a very important role in angiogenesis ,wound healing , and so on .HIF‐1αhas been shown to improve angiogenesis by binding to a hypoxia‐response element and to regulate the expression of vascular endothelial growth factor （VEGF） .This review aims to summarize the advance on HIF‐1αand its impact on angiogenesis in diabetes .

关 键 词：缺氧诱导因子-1Α 糖尿病 2型 血管新生 微小RNA 

分 类 号：R587.1[医药卫生—内分泌]