绝经前甲亢患者血OPG和RANKL水平变化及其与骨质疏松的关系  

Alteration of serous OPG and RANKL in premenopausal patients with hyperthyroidism and their association with osteoporosis

作　　者：薛丽萍[1] 胡红琳[1] 夏莉[1] 王长江[1] 

机构地区：[1]安徽医科大学第一附属医院内分泌科,合肥230022

出　　处：《安徽医学》2015年第4期433-436,共4页Anhui Medical Journal

摘　　要：目的测定绝经前弥漫性毒性甲状腺肿(甲亢)患者血清护骨素(OPG)、细胞核因子κB受体活化因子配基(RANKL)水平,了解其与骨质疏松的关系。方法选择40例绝经前甲亢患者为甲亢组,44例年龄匹配的绝经前健康女性为对照组。采用ELISA法测定受试者血清OPG和RANKL水平。采用双能X线骨密度吸收仪测定其腰椎(L2-4)、股骨颈、Ward三角和大粗隆区骨密度。结果与对照组比较,甲亢组血OPG和RANKL水平高于对照组,差异有统计学意义(P<0.05),OPG/RANKL水平低于对照组(P<0.05)。甲亢组血OPG、RANKL与骨密度呈负相关(P值均<0.05)。结论绝经前女性甲亢患者血OPG、RANKL水平升高,且其变化与骨代谢有关。Objective To determine the levels of OPG and RANKL in sera and their association with osteoporosis in premenopausal patients with hyperthyroidism. Methods Sera were taken from 40 premenopausal patients with hyperthyroidism,the experimental group,and 44 age-matched healthy female individuals,the control group,followed by ELISA to measure levels of OPG and RANKL in sera. Bone miner-al density (BMD)of lumbar vertebrae (L2-4 ),femoral neck,ward triangle and trochanter major were measured by dual energy X-ray ab-sorptiometry. Results Compared with normal controls,a notable increase in the levels of serum OPG and RANK,and a significant decrease in the ratio of OPG/RANKL were observed. Correlation analysis showed that both OPG and RANKL were correlated with BMD negatively(P<0. 05). Conclusion We have found that there is an increase in the levels of OPG and RANKL in sera of premenopausal patients with hy-perthyroidism,which is closely related to bone metabolism.

关 键 词：护骨素 细胞核因子κB受体活化因子配基 弥漫性毒性甲状腺肿 骨质疏松 

分 类 号：R580[医药卫生—内分泌] R581.1[医药卫生—内科学]