谷氨酰胺治疗急性放射性食管炎的疗效  

Glutamine for Acute Radiation Esophagitis

作　　者：马春曦[1] 邓兰[1] 彭国林[1] 杨尚凌[1] 宋建文[1] 许丽娟[1] 

机构地区：[1]中国人民解放军第184医院肿瘤科,江西鹰潭335000

出　　处：《南昌大学学报（医学版）》2015年第2期80-82,102,共4页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨谷氨酰胺对急性放射性食管炎的临床疗效。方法将62例胸部恶性肿瘤放疗患者随机分成谷氨酰胺组(n=31)和对照组(n=31),2组均采用三维适形放疗。从放疗的第1天至放疗结束后2周,谷氨酰胺组在早、中、晚三餐餐后30min和睡觉前服用0.15g·L-1谷氨酰胺25mL;对照组服用生理盐水,用法用量同谷氨酰胺组。采用临床症状RTOG评分标准和内镜Kuwaht’s评分系统比较2组急性放射性食管炎的发生情况。结果临床症状RTOG评分谷氨酰胺组2级及以上急性放射性食管炎发生率为22.58%,3级及以上急性放射性食管炎发生率为3.22%;对照组分别为61.29%、12.90%,对照组均显著高于谷氨酰胺组,差异具有统计学意义(P<0.05)。内镜Kuwaht’s评分谷氨酰胺组2级及以上急性放射性食管炎发生率为16.67%,对照组为55.56%,对照组显著高于谷氨酰胺组,差异具有统计学意义(P<0.05)。结论谷氨酰胺可减轻放疗对食管的毒性。Objective To investigate the clinical effect of glutamine on acute radiation esoph-agitis.Methods Sixty-two patients undergoing radiotherapy for thoracic malignancies were ran-domized into two groups,with 31 patients in each group.All patients received three-dimensional conformal radiotherapy.From the first day of radiotherapy to two weeks after the end of radio-therapy,the glutamine group was given 25 mL glutamine (0.15 g·L-1 )30 minutes after meals and at bedtime,respectively.The control group received an equal amount of normal saline.The oc-currence of acute radiation esophagitis was evaluated using RTOG scoring system and Kuwaht’s criteria.Results According to RTOG scoring system,the grade 2 or worse acute esophagitis was observed in 22.58% of patients in glutamine group and 61.29% of patients in control group,and the grade 3 or worse acute esophagitis was observed in 3.22% of patients in glutamine group and 12.90% of patients in control group.According Kuwaht’s criteria,the grade 2 or worse acute esophagitis was observed in 16.67% of patients in glutamine group and 55.56% of patients in control group.The incidence of grade 2 or worse acute esophagitis in glutamine group was signifi-cantly lower than that in control group (P <0.05).Conclusion Glutamine can reduce the esopha-geal toxicity induced by radiotherapy.

关 键 词：谷氨酰胺 胸部恶性肿瘤 放射治疗 急性放射性食管炎 

分 类 号：R818[医药卫生—放射医学]