Schwann cells and fibronectin treating lesioned spinal cord of adult rats  

作　　者：赵寅涛 李立新 戴建础 

机构地区：[1]DepartmentofNeurosurgery,GulouHospital,Nanjing210008,China

出　　处：《Chinese Journal of Traumatology》1999年第2期110-114,共5页中华创伤杂志（英文版）

摘　　要：Objective: To determine whether Schwann cells (SCs) and fibronectin (FN) support the growth of damaged axons and their conductive function. Methods: Thirty adult Sprague Dawley (SD) rats were randomized into 3 groups (n=10), and the following grafts: both SCs and FN, FN, and basal medium were implanted respectively into the lumbar of spinal cords hemisected at vertebra T 12 . Results: At 6 weeks postoperation, the latencies of spinal cord evoked potential (SCEP) P 1 wave in the three groups were 1.57 ms, 1.84 ms, and 2.03 ms, respectively. The differences between SCs/FN group and the other two groups were statistically significant. The number of regenerated axons in SCs/FN group was significantly greater than that in FN group. The number of survival neurons in L 4 and L 5 left dorsal root ganglia (DRG) in SCs/FN group was significantly greater than that in the rest two groups respectively. The latencies of P 1 wave were significantly correlated with axon counts in both SCs/FN and FN groups. Conclusions: SCs/FN grafted to the hemisected lumbar of spinal cords can produce robust axon regeneration and promote partial repair of their conduction. Surface recording of SCEP technique has been proved to be a reliable and less traumatic method for assessment of recovery of afferent conduction in hemisected spinal cord.

关 键 词：Schwann cells  Fibronectins  Graft survival  Regeneration 

分 类 号：R651.2[医药卫生—外科学]