法舒地尔对早期糖尿病肾病患者氧化应激的影响  

The influence of Fasudil on oxidative stress in patients with early-stage diabetic nephropathy

作　　者：徐美荣[1] 吴甘霖[2] 

机构地区：[1]湖北科技学院附属二医院内科,湖北省咸宁市437100 [2]湖北科技学院临床医学院内科,湖北省咸宁市437100

出　　处：《实用医学杂志》2015年第8期1318-1320,共3页The Journal of Practical Medicine

基　　金：湖北省教育厅青年基金(编号:Q20132803);湖北科技学院博士启动基金(编号:BK1212)

摘　　要：目的:探讨法舒地尔对早期糖尿病肾病患者氧化应激的影响。方法:将48例早期糖尿病肾病患者随机分为硫辛酸组、法舒地尔组。所有患者严格控制血糖,治疗2周后观察血清胱抑素C(Cysc)、尿微量白蛋白(m ALB)、尿8-羟基脱氧鸟苷(8-OHd G)变化。结果:与治疗前相比,治疗后硫辛酸组和法舒地尔组尿m ALB、血清Cysc和尿8-OHd G水平均明显下降;治疗前和治疗后两组之间血清Cysc、尿m ALB和8-OHd G水平比较,差异无显著性。结论:法舒地尔对早期糖尿病患者有肾脏保护作用,其保护作用机制可能与降低8-OHd G的水平、减轻氧化应激有关。Objective To investigate the influence of Fasudil on oxidative stress in patients with early- stage diabetic nephropathy. Methods 48 patients with earl-stage diabetic nephopathy were randomly divided into control group treated with Alpha-lipoic acid and treametn group with Fasudil. All patients were under strict control of blood glucose. Changes in the levels of serum cysc, urinal mALB and 8-OHdG were observed after two weeks treatment were compared between the two groups. Results Compared to pre-treatment, the content of serum cysc, urinal mALB and 8-OHdG were significantly decreased in both groups after treatment. There was no significant difference in the content of urine mAlb, CTGF and MCP-1 between the two groups before and after treatment （P 〉 0.05）. Conclusion Fasudil may protect kidney through a mechanism by which the level of 8-OHdG in kidney is decreased and oxidative stress is alleviated.

关 键 词：糖尿病肾病 法舒地尔 8-OHd G 

分 类 号：R587.2[医药卫生—内分泌]