不同透析频率对维持性血液透析患者贫血状况的影响  

Effects of different dialysis frequencies on the anemia in maintenance hemodialysis patients

作　　者：王伟[1] 岳华[1] 

机构地区：[1]新疆维吾尔自治区人民医院肾病科,新疆乌鲁木齐830002

出　　处：《国际泌尿系统杂志》2015年第3期406-410,共5页International Journal of Urology and Nephrology

摘　　要：目的研究不同透析频率对维持性血液透析患者的贫血的影响。方法选取新疆维吾尔自治区人民医院血净中心MHD患者，年龄超过18岁，透析龄在1年以上，透析方式均采用Fx60高通量血液透析，每次透析时间均为4h。根据透析方案的不同将维持性血液透析患者分为3组。A组：每周透析4次；B组：每周透析3次；C组：每周透析2次。所有患者均根据指南常规给予降压、补充促红素、铁剂、维生素、叶酸及活性维生素D3等。分别观察各组患者基线及透析1年后的HGB、血清铁蛋白、转铁饱和度、维生素B12、叶酸、ALB、CRP、Scr、BUN、PTH。结果资料完整的患者共67例，其中男33例，女34例，年龄21～80岁，平均年龄（55±14）岁，其中A组共16例：男9例，女7例；B组共27例：男13例，女14例；C组共24例：男11例，女13例。A、B、C三组患者基本资料对比及基线各项指标对比差异均无统计学意义（P〉0．05）。透析1年后三组患者的HGB、CRP、ALB、BUN、Scr、PTH差异均有统计学意义（P〈0．05），而血清铁蛋白、转铁饱和度、维生素B12、叶酸、Kt／v对比差异无统计学意义。透析1年后三组间两两比较，A组与c组比较HGB、ALB、CRP、Scr、BUN、PTH差异均有统计学意义（P〈0．05）；B组与C组比较HGB、ALB、CRP、Scr、PTH差异有统计学意义（P〈0．05）；A组与B组比较所有指标差异均无统计学意义（P〉0．05）。结论每周透析4次及3次的患贫血状况较每周透析2次的要好，每周透析4次与每周透析3次的患者差异不大。所以维持性血液透析患者保证每周透析3次，在改善营贫血状况有着重要的临床意义。Objectives To research the effects of different dialysis frequencies on anemia in maintenance hemodialysis patients. Methods To select patients from Xing Jiang Municipal People Hospital： age 〉 18 years, di- alysis age 〉 3 months. All patients were divided into 3 groups. Patients in group A dialysed 4 times per week. Pa- tients in group B dialysed 3 times per week. To investigate the index of HGB, Fer, Transferrin saturation, vitamin B12, folate,ALB,CRP,Scr,BUN,PTH. Results A total of 67 patients with maintenance hemodialysis were re- cruited. All indexes in group of A, B and C are no statistical significance（ P 〉 0.05）. After dialysed for 1 year the indexes include ALB, HGB, Scr , BUN, CRP, PTH are statistical significance（ P 〈 0.05 ）. The indexes include , Fer, Transferrin saturation, vitamin B12, folate are no statistical significance. There is statistical significance between group A and C on weight, ALB, HGB, Scr , BUN, CRP, PTH. There is also statistical significance between group B and Con ALB, HGB, Scr, CRP, PTH. There is no statistical significance between group A and B on any index. Conclusions The anemia status of the maintenance hemodialysis patients of the dialysis 3 ~ 4 times every week is better than the dialysis twice a week. The difference between the 4 times dialysis and the 3 times dialysis every week is few. So it is important clinical significance to guarantee three times dialysis a week for maintenance hemodialysis patients.

关 键 词：肾透析 贫血 

分 类 号：R459.5[医药卫生—治疗学]