基于数据挖掘的藏族医学经典《四部医典》治疗热性肝病方剂配伍规律  

Studying Composition Rules of Tibetan Medicinal Formulas Used to Treat Heat Illnesses of Liver in Four Tantra(rGyud bZhi ) Based on Data Mining

作　　者：才让南加[1] 仁增多杰[1] 

机构地区：[1]青海大学藏医学院,西宁810001

出　　处：《中国实验方剂学杂志》2015年第10期216-219,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：青海省自然科学基金青年项目(2013-Z-939Q);青海大学医学院中青年科研基金团队项目(2014-KT-3)

摘　　要：目的:探讨《四部医典》治疗热性肝病藏药方剂配伍规律及其理论依据。方法:整理《四部医典》中所有治疗热性肝病的方剂,并用统计软件Cran R进行频数统计和关联规则分析。结果:发现治疗热性肝病的67首方剂,由95味药材配伍而成,其中使用频率最高的10味药分别是藏红花、天竺黄、印度獐牙菜、牛黄、诃子、闸驯、鸭嘴花、兔耳草、檀香和丁香,累计用药频率达46.26%。发现支持度>0.1,置信度>0.7的关联规则共204条,整理后挖掘出诃子-毛诃子-余甘子,天竺黄-牛黄-藏红花-兔耳草-印度獐牙菜-甘青乌头等6组核心药物组合。结论:用药频率较高的药物均以清热药为主,味苦、甘者居多。其中,使用频率最高的藏红花有着清热、保肝的作用,并且作为治疗肝病药引子在使用;挖掘出治疗热性肝病方剂的药物关联规则多数以清热药和保肝药配伍而成,药味组合以甘味和苦味组合为主,性效上以凉、钝为主,具有平和赤巴之热、锐等病性的特点。本文揭示了《四部医典》治疗热性肝病方剂具有严谨的配伍理论;藏药"性、效、味"理论对常规临床用药和个体化治疗、以及新药开发具有很强的指导意义。Objective： The aim of this article was to discuss the composition rules of Tibetan medicinal formulas used to treat heat illnesses of the liver. Method ： Formulas described for treating heat illnesses of the liver （mchin tshad） were selected from the rGyud bZhi. Frequency and association rules were analyzed by the statistical computing CRAN R software. Result： In this study, 67 Tibetan medicinal formulas including 95 ingredients were found for treating liver heat illnesses. Among these formulas, the top 10 ingredients frequently used are： StigmaCroci, Calciosinti, Herba Swertiae Chirayitae, Bovis Calculus, Chebulae Fructus, Brag Zhun, Adhatoda Vasica, Herba Lagotis, Santali Albi Lignum and Caryophylli Flos. These 10 ingredients comprised 46.26% of the extracted formulas. A total of 204 association rules were found with a support value higher than 1 and a confidence higher than 0.7. Totally, 6 most frequently cited association groups were derived, as the following： Chebulae Fructus-Fructus Termlnallae Billericae-Fructus Phyllanthi; Calciosinti-Bovis Calculus-Stigma Croci-Herba Lagotis- Herba Swertiae Chirayitae-Herba Aconiti Tangutiei; Adhatoda Vasica-Calciosinti-Stigma Croci-Herba Swertiae Chirayitae-Bovis Calculu; Calciosinti-Stigma Croci-Santali Albi Lignum-Herba Lagotis; Fel Ursi-Stigma Croci-Brag Zhun; Bovis Calculus-Stigma Croci-Santali Albi Lignum-Calciosinti. Conclusion： The most common characteristic of the ingredients among the formulas derived is their cooling activity, as they are the common compounds used to treat general heat illnesses. Stigma Croci, the most frequently used compound has the effect of removing pathogenic heat and protecting the liver. Stigma Croci is also commonly used to enhance the efficacy of other formulas fortreating the liver. The most commonly occurring compound groups derived by the current study all contain compounds which can protect liver and treat heat illnesses generally. Their taste composition is primarily sweet and bitter, which are the tastes describe

关 键 词：藏族医药 方剂 热性肝病 配伍规律 数据挖掘 

分 类 号：R287.6[医药卫生—中药学]