胸腔镜下手术对肺癌患者血流动力学及免疫功能的影响  

Comparative study on the effect of thoracoscope surgery and traditional open surgery on hemodynamics and immune function of lung cancer patients

作　　者：周松林[1] 徐文波[2] 

机构地区：[1]江西省胸科医院心血管内科,江西南昌330006 [2]广东省深圳市坪山新区人民医院彩超室,广东深圳518118

出　　处：《中国内镜杂志》2015年第4期344-347,共4页China Journal of Endoscopy

摘　　要：目的分析胸腔镜下手术和传统开胸手术对肺癌患者血流动力学及免疫功能影响的差异。方法选择在该院接受住院治疗的108例肺癌患者作为研究对象,随机分为接受开放手术治疗的对照组以及接受胸腔镜手术治疗的观察组,比较两组的手术相关指标、血流动力学指标及免疫功能指标等差异。结果观察组患者接受胸腔镜手术治疗后的手术时间长于对照组,术中出血量和术后引流量均少于对照组,术后下床时间及总住院时间明显短于对照组患者(P<0.05)。单肺通气结束时及手术结束时观察组患者的各项血流动力学指标均明显低于对照组患者(P<0.05)。观察组患者接受胸腔镜手术治疗后的CD4+、CD8+、CD4+/CD8+及NK细胞比例等值均明显高于对照组患者(P<0.05)。结论胸腔镜下肺癌根治术较传统开胸手术具有明显优势,在保持围术期血流动力学水平稳定的同时,还可以避免患者的免疫功能被过度抑制。[ Objective ] To analyze the effect of thoracoscope surgery and traditional open surgery on hemody- namies and immune function of lung cancer patients. [Methods ] 108 patients with lung cancer were chosen as re- search object, randomly divided into control group treated with open surgery and observation group treated with tho- raeoseope surgery. Then operation related indicators, hemodynamic index and immune function index in two groups were compared. [ Results ] The surgery time in observation group was longer than that in control group. The intraop- erative blood loss and postoperative flow were less than those in control group. The postoperative bed time and total hospitalization time were significantly shorter （P 〈0.05）. The hemodynamic indexes for single lung ventilation and surgery in observation group of patients were significantly lower than those in control group （P 〈0.05）. The CD4＋, CD8＋, CD4＋/CD8＋ and NK cells percentage in observation group were significantly higher than control group （P 〈0.05）. [ Conclusion ] Thoracoscopic lung resection had obvious advantages over traditional open surgery, while maintaining a stable level of perioperative blood flow dynamics, but also avoiding the immune function being excessive inhibited.

关 键 词：肺癌 胸腔镜 血流动力学 免疫功能 

分 类 号：R655.3[医药卫生—外科学]