普米克令舒联合硫酸镁治疗新生儿胎粪吸入综合征的临床研究  

Clinical study of Pulmicort Respules combined with Magnesium Sulfate in the treatment of neonatal meconium aspiration syndrome

作　　者：罗思华[1] 唐渊[1] 梁创[1] 吴锦媛[1] 

机构地区：[1]广东省茂名市人民医院儿科,广东茂名525000

出　　处：《中国医药导报》2015年第14期125-128,共4页China Medical Herald

基　　金：广东省茂名市科技计划项目(20140332)

摘　　要：目的探讨普米克令舒联合硫酸镁治疗新生儿胎粪吸入综合征的临床效果。方法纳入广东省茂名市人民医院2010年4月～2014年4月收治的新生儿胎粪吸入综合征患儿123例。将其分为观察组（n=43）、硫酸镁组（n=40）、普米克令舒组（n=40）。观察组采用普米克令舒联合硫酸镁治疗，硫酸镁组给予硫酸镁治疗，普米克令舒组给予普米克令舒治疗。对比分析三组患儿治疗前后动脉血气指标水平、肺动脉收缩压（PASP）、氧暴露时间、住院时间及疗效。结果观察组治疗后12、24hpH与同期硫酸镁组和普米克令舒组比较差异无统计学意义（P〉0．05），血氧分压明显高于硫酸镁组和普米克令舒组，动脉血二氧化碳分压明显低于硫酸镁组和普米克令舒组，差异均有统计学意义（P〈0．05）；观察组治疗后12、24hPASP水平明显低于硫酸镁组和普米克令舒组，差异有统计学意义（P〈0．05）；观察组氧暴露时间[（5．49±0．85）d]和住院时间[（12．95±2．31）d]均显著短于硫酸镁组[（7．93±1．12）、（16．41±2．57）d]及普米克令舒组[（7．78±1．05）、（16．23±2．41）d]，差异有统计学意义（P〈0．05）；观察组总有效率（86．05％）显著高于硫酸镁组（65．00％）和普米克令舒组（62．50％），差异有统计学意义（P〈0．05）。结论普米克令舒联合硫酸镁治疗新生儿胎粪吸入综合征临床效果显著，具有重要的临床研究价值。Objective To investigate the clinical effect of Pulmicort Respules combined with Magnesium sulfate in the treatment of neonatal meconium aspiration syndrome. Methods 123 cases of children with neonatal meconium aspiration syndrome admitted to Maoming People＇s Hospital from April 2010 to April 2014 were enrolled, and they were divided into observation group （n = 43）, Magnesium Sulfate group （n = 40）, Pulmicort Respules group （n = 40）. The observation group was given Pulmicort Respules combined with Magnesium Sulfate, Magnesium Sulfate group was given Magnesium Sulfate, Pulmicort Respules group received Pulmicort Respules. The levels of arterial blood gas indexes, pulmonary artery systolic pressure （PASP）, oxygen exposure time, hospitalization time and curative effect before and after treatment among the three groups were compared and analyzed. Results The pH after treatment for 12, 24 h in observation group had no statistically significant differences compared with Magnesium Sulfate group and Pulmicort Respules group at the same time （P 〉 0.05）, PaO2 of observation group was significantly higher than that of Magnesium Sulfate group and Pulmicort Respules group, PaCO2 was significantly lower than that of Magnesium Sulfate group and Pulmicort Respules group, the differences were statistically significant （P 〈 0.05）; the level of PASP after treatment for 12, 24 h in observation group was significantly lower than that of Magnesium Sulfate group and Pulmicort Respules group, the differences were statistically significant （P 〈 0.05）; the oxygen exposure time [（5.49±0.85） d] and length of stay [（12.95±2.31） d] of observation group were significantly shorter than Magnesium Sulfate group [（7.93±1.12）, （16.41±2.57） d] and Pulmicort Respules group [（7.78±1.05）, （16.23±2.41） d], the differences were statistically significant （P 〈 0.05）; the total effective rate of the observation group （86.05%） was significantly higher than that of Magnesium Sulfate g

关 键 词：普米克令舒 硫酸镁 新生儿胎粪吸入综合征 

分 类 号：R722.12[医药卫生—儿科]