人乳头瘤病毒DNA检测和宫颈细胞学检查对宫颈癌前病变筛查的效果  

The effect of human papillomavirus DNA testing and cervical cytology for screening of cervical precancerous lesions

作　　者：梁瑜[1] 彭华丽[1] 

机构地区：[1]广东省信宜市中医院妇科,广东信宜525300

出　　处：《中国当代医药》2015年第13期124-125,128,共3页China Modern Medicine

摘　　要：目的：探讨人乳头瘤病毒（HPV）DNA检测和宫颈细胞学检查对宫颈癌前病变筛查的效果。方法选取2013年1月-2014年6月来本院就诊并进行宫颈癌前病变筛查的1100例患者，均进行HPV DNA检测、宫颈细胞学检查、阴道镜检查与宫颈活检，以病理诊断为标准，对检测结果进行分析。结果1100例患者中，HPV DNA阳性率为23.00豫，其中宫颈癌阳性率为83.33豫，宫颈上皮内瘤变（CIN）Ⅰ阳性率为44.44豫，CINⅡ阳性率为86.67豫，CINⅢ阳性率为94.12豫。宫颈细胞学检查无CIN 851例（77.36豫），非典型鳞状上皮细胞139例（12.64豫），低度鳞状上皮细胞内病变78例（7.09豫），高度鳞状上皮细胞内病变29例（2.64豫），鳞状细胞癌3例（0.27豫）。阴道镜检查与病理诊断符合率为62.79豫（54/86）。结论针对就诊患者采取合适的宫颈癌前病变筛查方法有助于提高检出率，降低宫颈癌发生率。Objective To investigate the effect of human papillomavirus （HPV） DNA testing and cervical cytology screening of cervical precancerous lesions. Methods 1100 patients admitted to our hospital who were carried out screening cervical precancerous lesions from January 2013 to June 2014 were selected,all were carried out HPV DNA testing,cervical cytology,colposcopy and cervical biopsy,pathological diagnosis was as the standard,the test results were analyzed. Results Positive rate of HPV DNA testing was 23.00% in 1100 patients,in which,positive rate of cervical cancer was 83.33%,positive rate of cervical intraepithelial neoplasia （CIN） Ⅰ was 44.44%,CIN II testing was 86.67%, CINⅢ positive rate was 94.12%.Cervical cytology results showed that there were 851 cases （77.36%） with no CIN,139 cases （12.64%） were atypical squamous cells,78 cases （7.09%） were low-grade squamous intraepithelial lesion,29 cases （2.64%） of high-grade squamous intraepithelial cells lesions,3 cases （0.27%） of squamous cell carcinoma.The compli-ance rate of colposcopy examination and pathological diagnosis was 62.79% （54/86）. Conclusion The suitable cervical lesions screening method for patients can help to improve the detection rate,reduce the incidence rate of cervical cancer.

关 键 词：人乳头瘤病毒DNA检测 宫颈细胞学检查 宫颈癌 筛查 

分 类 号：R711.74[医药卫生—妇产科学]