纳米晶胶原人工骨用于新疆维吾尔自治区塔城地区哈萨克族人的牙槽嵴保存  

Nano-collagen artificial bone for alveolar ridge preservation in the Kazakh from Xinjiang Tacheng Region

作　　者：王程越[1] 赵远[2] 杨曼[2] 王树峰 

机构地区：[1]辽宁医学院附属口腔医学院.辽宁医学院附属第二医院口腔修复科,辽宁省锦州市121000 [2]辽宁医学院研究生学院,辽宁省锦州市121000 [3]徐州市口腔医院修复科,江苏省徐州市221000

出　　处：《中国组织工程研究》2015年第12期1864-1871,共8页Chinese Journal of Tissue Engineering Research

基　　金：塔城地区科学研究与技术开发(含攻关)项目(2013406)~~

摘　　要：背景:拔牙后牙槽嵴的保存是一个重要的课题。新疆维吾尔自治区塔城地区边疆各县少数民族牙齿拔出后,由于就诊条件、地理条件等限制以及当地居民缺乏口腔保健意识等诸多因素,缺牙区长时间未及时修复导致牙槽嵴条件较差,因此寻找一种适合当地的且更有效的保存剩余牙槽嵴的方法,在当地有着较实用的临床价值。目的:探索纳米晶胶原人工骨用于新疆维吾尔自治区塔城地区哈萨克族人牙槽嵴保存的可行性。方法:采用自身配对设计,选取68例新疆维吾尔自治区塔城地区哈萨克族双侧拔牙患者,对就诊的双侧拔牙患者实验侧和对照侧的确定按"不平衡指数最小的分配原则"分组,实验侧拔牙窝植入纳米晶胶原人工骨,对照侧拔牙窝常规处理。植入后即刻及植入后3个月应用螺旋CT对植入区感兴趣区扫描,测量骨密度。结果与结论:植入后即刻,患者实验侧和对照侧CT图像可见拔牙窝清晰的轮廓,牙槽间隔可见;植入后3个月,患者实验侧和对照侧CT图像显示拔牙窝牙槽间隔影像模糊,CT值与周围牙槽突CT值接近,但实验侧植骨区骨充盈;且植入后3个月患者实验侧骨密度高于对照侧。说明纳米晶胶原人工骨用于新疆维吾尔自治区塔城地区哈萨克族患者牙槽嵴保存的临床效果较好。BACKGROUND：It is an important issue of alveolar ridge preservation after tooth extraction. Because of the limited treatment and geographical conditions, lack of awareness of oral health, many local people in frontier areas in Xinjiang have poor alveolar ridge that is not of timely repair after tooth extraction. Thus, it is important to find a suitable local and efficient way to save the residual ridge, which has a more practical clinical value. OBJECTIVE：To investigate the feasibility of nano-colagen artificial bone used for alveolar ridge preservation in the Kazakh in Xinjiang Tacheng Region, China.＆nbsp;METHODS： Sixty-eight Kazakh patients with bilateral extraction from Tacheng region, Xingjiang Uygur Autonomous Region, China were selected in a self-controled trial. According to the principle of a minimum alocation imbalance index, the experimental side and control side of extraction patients were confirmed. In the experimental side, nano-colagen artificial bone was implanted; while, conventional treatment was done in the control side. Multi-slice spiral CT was used to scan the regions of extraction interest to measure the relative gray value of alveolar bone mineral density immediately and 3 months after implantation. RESULTS AND CONCLUSION：Immediately after implantation, tooth extraction sockets were visible on CT images both in the experimental and control sides; but after 3 months, the extraction sockets became unclear on the CT images, and CT values were close to those of the surrounding alveolar process, but bone tissues were ful of the bone graft area in the experimental side. The alveolar bone mineral density was higher in the experimental side than the control side at 3 months after implantation. These findings indicate that the nano-colagen artificial bone has good clinical achievement in alveolar ridge preservation in the Kazakh in Xinjiang Tacheng Region.

关 键 词：生物材料 口腔生物材料 纳米晶胶原人工骨 纳米生物材料 羟基磷灰石 骨缺损 骨引导 牙槽嵴 拔牙窝 

分 类 号：R318[医药卫生—生物医学工程]