Bcl-2基因家族研究进展  

Research progress of the Bcl- 2 gene family

作　　者：任玉伟[1] 宿华威[1] 

机构地区：[1]哈尔滨医科大学附属第二临床医院胆道,腹腔镜微创外科,黑龙江哈尔滨150086

出　　处：《大连医科大学学报》2015年第2期202-205,共4页Journal of Dalian Medical University

摘　　要：Bcl-2家族蛋白是细胞凋亡的关键调节分子,线粒体、内质网等在细胞凋亡的过程中扮演着重要的角色,Bcl-2家族蛋白可直接或间接作用于线粒体来发挥它们的相应功能。Bcl-2基因家族在缺血再灌注损伤(IRI)中也有着独特的地位。而且Bcl-2家族的表达和调控对肿瘤细胞凋亡也具有较大的影响,如何调控Bcl-2家族成员的表达和表达后的针对性治疗,成为今后研究的一个方向。本文对Bcl-2目前的研究进展作一综述。Bc1 -2 family proteins are key regulatory molecules of apoptosis. Mitochondria and endoplasmic reticulum etc. play important roles in the process of apoptosis. Bcl - 2 family proteins can have direct or indirect effects on mitochondria to play its function. Bc1-2 gene family has also a unique role in ischemia- reperfusion injury （IRI）. The expression and regulation of Bcl - 2 family has great influence on tumor cell apoptosis. How to regulate the expression of Bcl - 2 family members and the expression - related target therapy have become a direction of future research. This article summarizes the present research progress.

关 键 词：BCL-2 细胞凋亡 线粒体 内质网 缺血再灌注损伤 

分 类 号：R346[医药卫生—基础医学]