2型糖尿病肾病患者尿液Mindin的变化及意义  

Changes and significance of urinary mindin in type 2 diabetic patients with nephropathy

作　　者：邵雪景[1] 韦玉和[1] 冯小芬[1] 赵志勇[1] 印永 

机构地区：[1]江苏大学附属武进医院内分泌病科,213002

出　　处：《江苏医药》2015年第8期904-907,共4页Jiangsu Medical Journal

基　　金：常州市武进区社会发展基金(WS201319)

摘　　要：目的探讨2型糖尿病(T2DM)患者尿mindin与糖尿病肾病(DN)的关系。方法采用ELISA法测定90例T2DM患者(A组)和32例健康体检者(B组)尿mindin水平。依据尿白蛋白/尿肌酐相对值(ACR)水平,A组再分为无蛋白尿(A1组)、微量蛋白尿(A2组)和大量蛋白尿(A3组)三个亚组。检测并分析相关指标。结果 A组患者尿mindin相对值(MCR=尿mindin/尿肌酐)与尿微量蛋白、糖化血红蛋白、收缩压、病程、血肌酐和24-h尿蛋白呈正相关(P<0.05或P<0.01),与肾小球滤过率呈负相关(r=-0.395,P<0.01)。慢性肾脏病分期为1、2、3期患者的尿MCR递增:3期(16例)>2期(45例)>1期(24例)(P<0.01),且与ACR变化规律类似。结论尿mindin可能与T2DM患者肾损伤密切有关;联合检测尿mindin和尿微量白蛋白有助于发现早期DN。Objective To investigate the changes and significance of urinary mindin protein in type 2 diabetic patients with nephropathy .Methods Mindin protein in urine was determined using ELISA in 90 patients with type 2 diabetes mellitus（T2DM ,group A） and 32 healthy people（group B） . On the basis of urine albumin/creatinine ratio （ACR） ,group A was assigned into three subgroups of A1（ACR〈3 mg/mmol ,29 cases） ,A2（3 mg/mmol≤ACR≤30 mg/mmol ,29 cases） and A3（ACR〉30 mg/mmol ,32 cases） .The related clinical data and biochemical indexes were collected and analyzed . Results The urinary midin/creatinine ratio（MCR） was positively correlated with urine trace protein , glycated hemoglobin ,duration ,systolic blood pressure ,serum creatinine ,and urine 24-h protein （ P〈0 .05 or P〈0 .01 ） ,but negatively correlated with glomerular filtration rate （ r= -0 .395 , P〈0 .01） .The urinary MCR of group A was in an order of chronic kidney disease （CKD） stage 3 （16 cases）〉 CKD stage 2（45 cases）〉 CKD stage 1（24 cases） .The tendency of MCR change was similar to that of ACR .Conclusion Urinary mindin protein may be closely related with early renal injury in T2DM patients .Combined detection of urinary mindin and trace protein is helpful in finding early diabetic nephropathy .

关 键 词：Mindin蛋白 糖尿病肾病 2型糖尿病 

分 类 号：R587[医药卫生—内分泌]