氧化苦参碱对急性心肌梗死家兔心功能和左心室重构的影响  

Effect of Oxymatrine on cardiac function and left ventricular remodeling in rabbits after acute myocardial infarction

作　　者：王雪芳[1] 刘艳明[2] 

机构地区：[1]河北北方学院生理教研室,张家口075000 [2]中国人民解放军251医院心内二科,河北张家口075000

出　　处：《中国应用生理学杂志》2015年第2期123-126,共4页Chinese Journal of Applied Physiology

基　　金：河北省教育厅青年基金资助项目(SQ132004);河北北方学院青年基金资助项目(Q2013032)

摘　　要：目的:研究氧化苦参碱对急性心肌梗死家兔模型心功能及左心室重构的影响。方法:采用结扎家兔左前降支建立急性心肌梗死模型,随机分为3组(n=9):假手术组、模型组、氧化苦参碱组,假手术组不结扎冠状动脉。假手术组、模型组常规饲养,氧化苦参碱组在正常饲养基础上用灌胃给药氧化苦参碱1 ml/100 g,每日1次,分别在术后1周、4周观察氧化苦参碱对家兔左心室腔内直径(D)、心室重量指数(VWI)、心室重量(VW)、体重(BW)、心输出量(CO)和左心室收缩末期压(LVESP)、左心室舒张末期压(LVEDP)、左室内压变化率峰值(dp/dtmax)的影响。结果:与假手术组比较,模型组心脏游离左室壁梗死范围由粉红色变为深紫色。术后1周模型组与假手术组相比CO减少(P<0.05),术后4周进一步减少(P<0.01)。术后1周、4周氧化苦参碱组与模型组相比CO明显增加(P<0.01),dp/dtmax增加(P<0.05),LVESP明显升高(P<0.01),LVEDP明显下降(P<0.01);术后4周氧化苦参碱组与模型组相比,D明显减小(P<0.01),VWI、VW减小(P<0.05)。结论:氧化苦参碱能增加急性心肌梗死后心输出量,改善急性心肌梗死家兔左心室重构参数,改善心功能指标。Objective： To observe the effect of Oxymatrine on left cardiac function and ventricular remodeling in rabbits after acute my- ocardial infarction. Methods： Ligation of the left anterior descending artery was adopted to establish acute myocardial infarction model, forty eight rabbits were randomized into the sham operation group, model group and Oxymatrine group. Eight models were successfully established in each group, the sham operation group and model group were given conventional feed. Oxymatrlne were gavage administration 0.5 ml/100 g, once a day, lasted for 4 weeks. Respectively in postoperative week, and three weeks, to observe the Oxymatrine on cardiac output （CO） , left ventriculax end systolic pressure （LVESP）, left ventricular end-diastolic pressure （LVEDP）, left indoor pressure change rate peak （dp/dtmax）, and left ventricular cavity internal diameter （D）, ventricular weight index （VWI）, ventricular weight （VW）. Results： Left ventricular anterior wall was from red to deep purple, electrocardiogram showed Ⅱ guide ST-segment camber up ≥ 0.25 my. Postoperative week in Oxymatrine group compared with model group, LVESP increased significantly （ P 〈 0.01）, LVEDP decreased obviously （ P 〈 0.01） ; After three weeks in Oxymatrine group compared with model group, VW, VWI decreased（ P 〈 0.05）, D significantly reduced （ P 〈 0.01 ） ; LVESP increased sig- nificantly （P 〈 0.01 ）, LVEDP decreased obviously （P 〈 0.01 ）; dp/dtmax, CO increased （P 〈 0.05）. Conclusion： After acute myocardial infarction in rabbit Oxymatrine can improve the left ventricular reconstruction parameters, increase cardiac output, and improve cardiac func- tion.

关 键 词：氧化苦参碱 心肌梗死 左心室重构 心输出量 家兔 

分 类 号：R542.22[医药卫生—心血管疾病]