细胞自噬与肝炎病毒感染的相关性研究  

Relationship between autophagy and hepatitis virus infection

作　　者：郭海清[1] 陈亚利[1] 段钟平[2] 任锋[3,4] 张晶[1] 

机构地区：[1]首都医科大学附属北京佑安医院中毒性肝病科,北京100069 [2]首都医科大学附属北京佑安医院人工肝中心,北京100069 [3]首都医科大学附属北京佑安医院 [4]北京市肝病研究所

出　　处：《胃肠病学和肝病学杂志》2015年第4期381-384,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：乙型重型肝炎肝衰竭优化诊疗方案研究(2012ZX10002004-006);重肝肝衰竭队列管理和规范化诊疗研究(2012ZX10004904-003-001);北京市卫生系统高层次卫生技术人才-学科骨干(2011-3-082;2013-3-075)

摘　　要：自噬(autophagy)又称细胞的自体溶解,是指隔离膜包裹胞浆蛋白和细胞器形成自噬体(autophagosome),然后与溶酶体融合成自噬溶酶体(autolysosome)并在其中降解的过程。自噬现象普遍存在于大部分真核细胞中,通过对细胞内变性蛋白或受损细胞器进行降解,以维持细胞内物质循环及代谢调节的稳定,在细胞生长、分化、功能执行、自我更新、衰老及死亡中发挥着重要调控功能。近期有大量研究表明,细胞自噬与肝炎病毒感染的发生、发展及预后有相关性。本文就自噬发生、演变过程中的分子机制及其与肝炎病毒感染的关系作一概述。[Abs rtact] Autophagy , also known as autocytolysis , is a process of lysosomal degradation of cytoplasmic protein and damaged organelles , which is widespread in most eukaryotic cells .It can maintain the stability of material circulation and metabolic regulation in the cells through the degradation of cellular components such as damaged organelles and de -natured protein and play an important regulatory function in cell growth , differentiation,function execution, self -renewal, aging and death .Recent studies have shown that there is a correlation between autophagy and the development and prog -nosis of hepatitis virus infection .Here, the relationship between molecular mechanisms of autophagy and hepatitis virus infection was reviewed .

关 键 词：自噬 自噬相关基因 乙型肝炎病毒 丙型肝炎病毒 

分 类 号：R512.6[医药卫生—内科学]