血清骨钙素水平与低促性腺激素性性腺功能减退症相关性研究  

Correlation between Serum Osteocalcin and Hypogonadotropic Hypogonadism

作　　者：孙超[1] 孙发[1,2] 邢俊平[3] 樊国军[1] 赵伊立 王成跃[1] 唐开发[1,2] 

机构地区：[1]贵阳医学院附院泌尿外科,贵州贵阳550004 [2]贵阳医学院医学科学研究所,贵州贵阳550004 [3]西安交通大学医学院第一附属医院泌尿外科,陕西西安710061

出　　处：《贵阳医学院学报》2015年第4期342-345,共4页Journal of Guiyang Medical College

基　　金：国家自然科学基金(81300541);贵州省科学技术基金计划项目[黔科合J字(2013)2051号];贵阳医学院附属医院博士基金(C-2012-6)

摘　　要：目的:通过测定低促性腺激素性性腺功能减退症(HH)患者血清骨钙素(OC)水平及性激素水平,探讨OC与HH的相关性。方法:HH患者98例为病例组,正常健康男性100例为对照组,采用酶联免疫吸附法(ELISA)检测两组外周血清OC、睾酮(T)、促卵泡生成素(FSH)、促黄体酮生成素(LH)、雌二醇(E2)、孕酮(P)和泌乳素(PRL)水平,并分析血清FSH、LH及T与血清OC的相关性。结果:病例组FSH、LH、T水平均明显低于对照组,差异有统计学意义(P<0.001);而PRL、P和E2在两组之间差异无统计学意义(P>0.05);病例组OC显著低于对照组(P<0.001);血清OC与T、FSH呈正性相关(β=0.490,β=0.240;P<0.001,P=0.001),与LH呈线性关系,但无统计学意义(β=0.093;P=0.175)。结论:血清OC水平与HH存在密切相关性。Objective：To detect the serum osteocalcin （OC）and sex hormone levels in patients with hypogonadotropic hypogonadism （HH）and discuss the correlation between OC and HH.Methods：Ninety-eight HH patients were selected as patient group and 100 healthy males as normal control group.Enzyme-linked immunosorbent assay （ELISA）was adopted to detect the serum OC and sex hormones including testosterone （T）,follicle stimulating hormone （FSH）,progesterone （LH）,estra-diol （E2）,progesterone （P）and prolactin （PRL）in patient group and normal control group.Re-sults：The FSH,LH,and T levels in patient group were significantly lower than their counterparts in control group （P 〈0.001）,while there was no statistical difference for PRL,P,and E2 between the two groups （P 〉0.05）.The OC level in patient group was significantly lower than that in normal con-trol group （P 〈0.001）.The serum levels of OC were positively related to T,FSH levels （β=0.490,β=0.240;P 〈0.001,P =0.001）.There was a linear relationship between OC and LH,but there was no significant difference （β=0.093;P =0.175）.Conclusions：The serum OC level is closely associ-ated with HH.

关 键 词：低促性腺激素性性腺功能减退症 骨钙素 睾酮 促卵泡生成素 促黄体酮生成素 人绒毛膜促性腺激素 

分 类 号：R691.9[医药卫生—泌尿科学]