2009-2013年某三甲医院感染病原菌分布及耐药性分析  

Distribution and drug resistance of pathogens in a hospital from 2009 to 2013

作　　者：程科萍[1] 孔庆芳[1] 李家伟[1] 王长娴[1] 叶南园 

机构地区：[1]东南大学附属中大医院感染管理科,江苏南京210009

出　　处：《中国微生态学杂志》2015年第3期296-300,共5页Chinese Journal of Microecology

基　　金：国家自然科学基金(81171433);美国国立卫生研究院(NIH)(1D43TW007257-01A2);中华医院感染控制研究基金(zhyy2013-11)

摘　　要：目的了解某三甲综合医院感染性病原菌的构成及细菌耐药性变迁,为抗菌药物的合理使用提供依据。方法对2009-2013年临床分离病原菌及其耐药性进行回顾性分析。结果革兰阴性杆菌对临床常用抗菌药物的耐药性,以氨苄西林、苯唑西林、头孢唑林的耐药率最高;对美罗培南、亚胺培南均较敏感,敏感率均为70%;克雷伯菌属对替卡西林耐药率为60%,不动杆菌属对头孢类和喹诺酮类耐药率很高。革兰阳性球菌对青霉素G、氨卞西林、苯唑西林、喹诺酮类的耐药率很高,都在50%以上。结论细菌耐药性仍是临床面临的严重问题,应加强对细菌耐药性的监测。Objective To investigate the composition and trends of drug-resistant bacteria in a tertiary comprehensive hospital, and provide a basis for rational use of antimicrobial drugs. Methods The pathogens clinically isolated from 2009 to 2013 and their resistance were retrospectively analyzed. Results The resistance rates of gramnegative bacilli to Ampicillin, Oxacillin and Cefazolin were the highest; Gram-negative bacilli were sensitive to Meropenem and Imipenem, both with the sensitivity rate of 70%. The resistanc rate of Klebsiella to Ticarcillin was 60% and those of Acinetobacter to Cephalosporins and Quinolones was very high. The resistance rates of gram-positive cocci to Penicillin, Ampicillin and Benzene cloxacillin were very high, which were more than 50%. Conclusion Bacterial resistance remains a serious clinical problem, and the monitoring should be strengthened.

关 键 词：病原菌 抗生素 耐药性 耐药监测 

分 类 号：R378[医药卫生—病原生物学]