母乳和新生儿粪便细菌与母乳性黄疸的相关性分析  

The correlation between bacteria in breast milk and newborn feces and breast milk jaundice

作　　者：茹彩旺 秦涛 王玲 江姗姗 吴福根 陈弘 

机构地区：[1]温岭市第一人民医院,浙江温岭317500

出　　处：《中国微生态学杂志》2015年第3期325-327,共3页Chinese Journal of Microecology

摘　　要：目的探讨母乳和新生儿粪便细菌与母乳性黄疸(BMJ)的相关性。方法以BMJ患儿为研究对象,并与健康新生儿对照。RT-PCR法检测母乳和新生儿粪便中细菌含量,比较BMJ组和对照组细菌含量的差别,分析血总胆红素与细菌含量的相关性。结果 (1)BMJ组母乳和新生儿粪便中青春双歧杆菌、两歧双歧杆菌和长双歧杆菌浓度显著低于对照组,差异均有统计学意义(均P<0.01);(2)母乳两歧双歧杆菌与血清TSB显著负相关(r=-534,P=0.000);新生儿粪便青春双歧杆菌(r=-0.675,P=0.000)、两歧双歧杆菌(r=-0.598,P=0.000)和长双歧杆菌(r=-0.472,P=0.000)与血清TSB显著负相关。结论母乳中双歧杆菌含量下降可能与新生儿BMJ相关。Objective To explore the correlation between bacteria in breast milk and newborn feces and breast milk jaundice （BMJ）. Methods 76 newborns with BMJ and their mothers were enrolled to the BMJ group, and 76 healthy newborns and their mothers were enrolled to the control group. The bacteria in breast milk and newborns＇ feces were detected with real-time polymerase chain reaction. The difference of bacteria content between the two groups was compared, and the correlation between serum bilirubin level and bacteria content was evaluated. Results The contents of Bifidobacterium adolescentis, Bifidobacterium bifidum and Bifidobacterium longum in breast milk and newborns feces in the BMJ group were significantly lower than those in the control group （ P 〈 0. 01 ）. Bifidobacterium bifidum in breast milk was significantly negatively correlated with the total serum bili- rubin （ r = - 534, P 〈 0.01 ） ; and the Bifidobacterium adolescentis, Bifidobacterium bifidum and Bifidobacterium longum in newborns feces were significantly positively correlated with the total serum bilirubin （r = -O. 675, - 0. 598, - 0. 472, P 〈 0. 01 ）. Conclusion The decline of the concentration of bifidobacterium species in breast milk may be associated with BMJ.

关 键 词：母乳性黄疸 细菌 母乳 粪便 新生儿 

分 类 号：R722.17[医药卫生—儿科]