不同真菌感染对降钙素原的差异与疾病预后的关系  

Difference in procalcitonin level of patients with fungal infections and its relationship with prognosis

作　　者：魏万昆[1] 万程彬[1] 张毅 

机构地区：[1]南阳市第二人民医院检验科,河南南阳473000 [2]河南省高等学校临床医学重点学科开放实验室,河南郑州450052

出　　处：《中华医院感染学杂志》2015年第9期1937-1939,共3页Chinese Journal of Nosocomiology

基　　金：河南省卫生厅科研基金资助项目(201203015)

摘　　要：目的观察不同真菌感染降钙素原的差异性,并对其与疾病预后的相关性进行分析。方法选取2012年6月-2013年6月于ICU就诊的危重病患者54例,根据危险评分分组,非危重组24例、危重组25例、极危重组5例;研究不同感染部位血清降钙素原水平、不同菌株感染血清降钙素原水平以及降钙素原与疾病预后的相关性。结果 54例真菌感染患者中肺部感染26例占48.15%、消化道感染12例占22.21%、泌尿道感染9例占16.67%、血流感染9例占12.96%;不同感染部位血清降钙素原水平具有一定差异性,其中血清降钙素原水平较其他部位明显偏高,差异有统计学意义(P<0.05);共培养出病原菌86株,其中白色假丝酵母菌占55.81%,热带假丝酵母菌占37.21%,克柔假丝酵母菌占6.98%,降钙素原水平差异无统计学意义;随着危重程度的不断升高,降钙素原水平逐渐增高,组间差异有统计学意义(P<0.05),PCT与危重评分呈正相关(P<0.05)。结论降钙素原对真菌感染的诊断有重大意义,但不同菌株间差异无显著性,其水平与疾病危重程度密切相关。OBJECTIVE To observe the difference in the procalcitonin level of the patients with different fungal in‐fections and explore its relationship with the prognosis of disease .METHODS A total of 54 critically ill patients who were treated in the ICU from Jun 2012 to Jun 2013 were enrolled in the study and divided into the non‐critical‐ly ill group with 24 cases ,the critically ill group with 25 cases ,and the extremely critically ill group with 5 cases according to the score of risk .The levels of procalcitonin of the patients with different sites of infections ,the levels of procalcitonin of the patients with infections due to different species of pathogens ,and the relationship between the level of procalcitonin and the prognosis of disease were observed .RESULTS The pulmonary infections oc‐curred in 26 （48 .15% ） of 54 patients w ith fungal infections ,of w hom 12 （22 .21% ） cases had the gastroin‐testinal tract infections ,9 （16 .67% ） cases had the urinary tract infections ,and 9 （12 .96% ） cases had the bloodstream infections .T he level of procalcitonin vaired in the patients w ith different sites of infections ,and the level of serum procalcitonin was higher ,there was significant difference （P〈0 .05） .Totally 86 strains of pathogens have been isolated ,of which 55 .81% were the Candida albicans ,37 .21% were the Candida tropicalis ,and 6 .98% were the Candida krusei ,there was no significant difference in the level of procalcito‐nin .The level of procalcitonin was significantly elevated with the increase of severity（P〈0 .05）;PCT was positively correlated with the score of severity （P〈0 .05） .CONCLUSION The level of procalcitonin has great significance in diagnosis of fungal infections and varies significantly in the different species of strains ,and it is closely related to the severity of disease .

关 键 词：真菌感染 降钙素原 疾病预后 关系分析 

分 类 号：R379[医药卫生—病原生物学]