不同乙型肝炎疫苗新生儿免疫应答的动态变化研究  

A study on immunologic response at different periods with different hepatitis B vaccine in infants

作　　者：周绍英[1] 边国林[1] 马瑞[1] 倪红霞[1] 方挺[1] 陈小英[1] 董红军[1] 

机构地区：[1]宁波市疾病预防控制中心,浙江宁波315010

出　　处：《浙江预防医学》2015年第5期466-468,476,共4页Zhejiang Journal of Preventive Medicine

基　　金：国家科学技术重大专项(2008ZX10002-001):艾滋病和病毒性肝炎等重大传染病防治;宁波市现场流行病学创新团队(2012B82018)

摘　　要：目的了解新生儿接种不同类型乙型肝炎(乙肝)疫苗(Hep B)后不同时期的免疫应答状况。方法选择余姚市和宁海县乙肝病毒表面抗原(HBs Ag)阴性母亲2 375人在2009年7月1日—12月31日分娩的新生儿作为研究对象,按照0、1、6个月免疫程序分别接种10μg重组Hep B和5μg重组Hep B疫苗,并在免后7个月、12个月和18个月分别采集静脉血进行免疫应答评价。结果免疫后7个月、12个月和18个月的抗-HBs的几何平均浓度,5μg Hep B-SCY分别为(714.79±3.50)、(259.89±3.87)和(78.38±4.04)m IU/m L,10μg Hep B-HPY分别为(2 420.76±3.51)、(703.55±3.46)和(171.32±3.76)m IU/m L,10μg组的几何平均浓度均高于5μg组(P均<0.01)。免后7、12、18月的抗-HBs低/无应答(<100 m IU/m L)率,5μg组分别为6.39%、23.33%和55.42%,10μg组分别为2.17%、5.17%和31.95%,5μg组均高于10μg组(P均<0.01)。结论不同时期10μg重组Hep B的免疫应答均优于5μg重组Hep B。Objective To know the immunologic response at different periods with different hepatitis B vaccine（HepB）in infants.Methods From July 1 to December 31 in 2009,the local infants born from hepatitis B virus（HBV）surface antigen （HBsAg）negative mother in Ninghai were selected and received a 0.5 ml of 5 -μg HepB made by recombinant deoxyribonucleic acid （DNA）techniques in saccharomyces cerevisiae yeast （HepB -SCY）and those in Yuyao were selected and received a 0.5 ml of 10 -μg HepB made by recombinant DNA techniques in hansenula polymorpha yeast （HepB -HPY）with a 0 -1 -6 month schedule.The specimens of blood were collected at 7 months,12 months and 18 months after vaccination for testing antibody.Results At 7 months,12 months and 18 months after vaccination,the geometric mean concentration （GMC）of Anti -HBs in HepB -SCY group were 714.79 ±3.50 mIU /mL,259.89 ± 3.87 mIU /mL and 78.38 ±4.04 mIU /mL,respectively.While in HepB -HPY group were 2 420.76 ±3.51 mIU /mL, 703.55 ±3.46 mIU /mL and 171.32 ±3.76 mIU /mL,respectively.There was statistical significant difference of GMC between HepB -SCY group and HepB -HPY group（P ＆lt;0.01）.The percent of antibody ＆lt;100 mIU /mL in HepB -SCY group were 6.39%,23.33% and 55.42%,and in HepB -HPY group,were 2.17%,5.17% and 31.95%,respectively. The difference between HepB -SCY group and HepB -HPY group had significantly statistical significance （P ＆lt;0.01 ）. Conclusion The immunologic response at different periods of HepB -HPY was better than that of HepB -SCY.

关 键 词：新生儿 乙型肝炎疫苗 免疫应答 

分 类 号：R186[医药卫生—流行病学]