Protective effect of ischemic preconditioning on liver  

作　　者：张燕忠 张柏根 潘仁龙 

机构地区：[1]VascularSurgery,AffiliatedRenjiHospital,ShanghaiSecondMedicalUniversity,Shanghai200001,China

出　　处：《Chinese Journal of Traumatology》2001年第2期123-125,共3页中华创伤杂志（英文版）

摘　　要：Objective:: To study the protective effect of ischemic preconditioning (IPC) on the hepatic ischemia-reperfusion injury. Methods: The model of rat liver subjected to ischemia/reperfusion (I/R) injury was made. All 24 mice were divided randomly into 3 groups and anesthetized by 2% sodium pentobarbital (30-40 mg/kg). The enzyme activity of AST, ALT, LDH, SOD and the content of LPO were assayed respectively. Specimens were observed under transmission electron microscope. Results: IPC prevented the increase of ALT, AST and LDH in the blood and that of LPO in the tissues (P< 0.05 ), and maintained high level of SOD in the tissues (P< 0.05 ). Conclusions: IPC has protective effect on the liver function.

关 键 词：Ischemic preconditioning LIVER Wounds and injuries ISCHEMIA-REPERFUSION 

分 类 号：R657.3[医药卫生—外科学]