强肾片对糖皮质激素大鼠骨质疏松的影响  

Effect of Qiang Shenpianon on osteoporosis induced by dexamethasone in rats

作　　者：郑继宇 吴永军 王世杰 秦培红 于耀宏[2] 臧凌鹤[2] 徐峰[2] 

机构地区：[1]辽宁好护士药业(集团)有限责任公司,本溪114004 [2]沈阳药科大学,沈阳110016

出　　处：《中药药理与临床》2015年第1期180-182,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的：探索强肾片对地塞米松致大鼠骨质疏松的影响。方法：建立糖皮质激素骨质疏松模型,测定强肾片给药后,骨密度,骨的生物力学等指标的变化。结果：强肾片能增加地塞米松骨质疏松模型大鼠股骨的骨密度和骨矿含量,降低血清骨钙素、碱性磷酸酶和酸性磷酸酶水平,增加尿磷排泄量和尿磷与肌酐的比值,降低羟脯氨酸与肌酐的比值,增加股骨的抗弯强度和最大弯曲力,增加胫骨骨小梁平均直径,使骨小梁结构趋于正常。强肾片125mg/kg起效,125~500mg/kg均产生显著效果。结论：强肾片对地塞米松大鼠骨质疏松有对抗作用。Objective： Search the effect of Qiang Shenpian on osteoporotic model induced by dexamethasone in rats. Methods： Dexamethasone rats model were introduced in the experiment. And the multi-sites bone index that can synthetically reflected bone intensity,bone desity were used as parameters afer Qiangshenpian was administrated. Results： Qiangshenpian could increase bone dencity of femur caused by dexamethasone. It could also ameliorate the macrostructure of trabecular bone of tibia. The levels of serum phosphorus,serum alkaline phosphatase and tartrate-resistant acid phosphatase,serum osteocalcin were returned closely to the normal levels. The excretion of urinary phosphorus induced,and urinary ca / cr,urinary Hpro / cr was rebounded. Above function were got at the dose of 125 mg / kg,it was conformed the function from 125 to 500 mg / kg doses. Conclusion： Qiang Shenpian have the anti-osteoporotic effect in dexamethasone rats.

关 键 词：强肾片 骨质疏松 糖皮质激素模型 

分 类 号：R285.5[医药卫生—中药学]