草木樨流浸膏片对类风湿性关节炎的疗效观察  

Effect of Melilotus Extract Tablets on patients of rheumatoid arthritis

作　　者：卢秀花[1] 

机构地区：[1]临沂市沂水中心医院,沂水276400

出　　处：《中药药理与临床》2015年第1期258-260,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:观察草木樨流浸膏片对类风湿性关节炎患者临床疗效及血清炎症因子的影响,探讨草木樨流浸膏片对类风湿性关节炎的作用机制。方法:将80例类风湿性关节炎患者随机分为两组,试验组给予草木樨流浸膏片800mg,tid,对照组给予双氯芬酸钠片50mg,tid,分别于治疗前及治疗6周后评估患者病情活动性,采用酶联免疫法测定各受试者血清中炎症因子的浓度。结果:(1)治疗前,两组患者病情活动指标:晨僵时间、关节疼痛个数、关节压痛级别、类风湿因子、血沉、C反应蛋白评价指标无显著差异;炎症因子水平无显著差异;(2)治疗6周后∶两组受试者病情明显改善,草木樨流浸膏片800mg(tid)组有效率明显高于对照组;其中与对照组相比,晨僵时间、关节疼痛级别试验指标差异具有显著性(P<0.05),炎症因子水平明显降低(P<0.05),其中TNF-α降低26.6±3.1(pg/ml),IL-6降低0.9±0.4(pg/ml),且胃肠道不良反应发生率(1/40)显著低于对照组(5/40)。结论:草木樨流浸膏片对类风湿性关节炎患者具有明显的临床疗效,其机制可能与调节患者炎症因子水平有关。Objective： To observe the effect of Melilotus Extract Tablets on serum inflammatory cytokines（ TNF-α、IL-6） in patients of rheumatoid arthritis（ RA）. Methods： The 80 RA patients were randomly divided into 2 groups： treatment group and control group,the treatment group received Melilotus Extract Tablets 800 mg,three times a day,the control group received diclofenac 50 mg,three times a day. After 6 weeks of treatment,rheumatoid arthritis disease activity index were recorded,serum inflammatory cytokines of TNF-α and IL-6 were determined by radioimmunoassay method. Results： 6 weeks after treatment,all clinical symptoms of RA were relieved significantly,Compared with control group,Melilotus Extract Tablets（ 800 mg,tid） can markedly improve morning stiffness and CRP,and had lower gastrointestinal tract ADRs.Melilotus Extract Tablets（ 800 mg,tid） can markedly reduce inflammatory cytokines of TNF-α and IL-6. Conclusion： Melilotus Extract Tablets can reduce serum inflammatory cytokines of TNF-α and IL-6,Melilotus Extract Tablets is an ideal medicine in treating rheumatoid arthritis.

关 键 词：草木樨流浸膏片 类风湿性关节炎 TNF-Α IL-6 

分 类 号：R285.6[医药卫生—中药学]